Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection

Targeting signaling pathways in neurodegenerative diseases: Quercetin's cellular and molecular mechanisms for neuroprotection Md. Rezaul Islam Department of Pharmacy, Faculty of Health and Life Sciences Daffodil International University Daffodil Smart City Bangladesh https://orcid.org/0000-0001-6949-8837 Md. Ibrahim Khalil Al‐Imran Department of Pharmacy, Faculty of Health and Life Sciences Daffodil International University Daffodil Smart City Bangladesh Mehrukh Zehravi Department of Clinical Pharmacy College of Dentistry and Pharmacy, Buraydah Private Colleges Buraydah Saudi Arabia Sherouk Hussein Sweilam Department of Pharmacognosy College of Pharmacy, Prince Sattam Bin Abdulaziz University Al‐Kharj Saudi Arabia Department of Pharmacognosy, Faculty of Pharmacy Egyptian Russian University Cairo Egypt Mohammad Rakib Mortuza Department of Chemistry and Biochemistry Lamar University Beaumont Texas USA Jeetendra Kumar Gupta Department of Pharmacology Institute of Pharmaceutical Research, GLA University Mathura India Thukani Sathanantham Shanmugarajan Department of Pharmaceutics, School of Pharmaceutical Sciences Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai India Kadirvel Devi Department of Pharmaceutics, School of Pharmaceutical Sciences Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai India Tanuja Tummala Department of Polymer Chemistry Pittsburg State University Pittsburg Kansas USA Mohammed Ali Alshehri Department of Biology, Faculty of Science University of Tabuk Tabuk Saudi Arabia Kalirajan Rajagopal Department of Pharmaceutical Chemistry JSS College of Pharmacy, JSS Academy of Higher Education and Research Ooty India Mohammed Asiri Department of Clinical Laboratory Sciences College of Applied Medical Science, King Khalid University Abha Saudi Arabia Irfan Ahmad Department of Clinical Laboratory Sciences College of Applied Medical Science, King Khalid University Abha Saudi Arabia Talha Bin Emran Department of Pharmacy, Faculty of Health and Life Sciences Daffodil International University Daffodil Smart City Bangladesh Abstract Background

Neurodegenerative diseases (NDs), including Alzheimer‘s disease, Parkinson‘s disease, and Huntington‘s disease, are complex and challenging due to their intricate pathophysiology and limited treatment options.
Methods

This review systematically sourced articles related to neurodegenerative diseases, neurodegeneration, quercetin, and clinical studies from primary medical databases, including Scopus, PubMed, and Web of Science.
Results

Recent studies have included quercetin to impact the cellular and molecular pathways involved in neurodegeneration. Quercetin, a flavonoid abundant in vegetables and fruits, is gaining attention for its antioxidant, anti‐inflammatory, and antiapoptotic properties. It regulates signaling pathways such as nuclear factor‐κB (NF‐κB), sirtuins, and phosphatidylinositol 3‐kinase/protein kinase B (PI3K/Akt). These pathways are essential for cellular survival, inflammation regulation, and apoptosis. Preclinical and clinical studies have shown that quercetin improves symptoms and pathology in neurodegenerative models, indicating promising outcomes.
Conclusions

The study explores the potential of incorporating laboratory research into practical medical treatment, focusing on quercetin‘s neuroprotective effects on NDs and its optimal dosage.
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