Synthesis, Characterization, Antimicrobial Evaluation of 2-Amino pyrimidine Schiff base derivative

Schiff base or imine is an analogue of a ketone or aldehyde in which the carbonyl group has been replaced by an
imine or azomethine group. Schiff bases exhibits a broad range of biological activities, including antifungal,
antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties Imine or
azomethine groups are present in various natural, natural-derived and non-natural compounds. The imine group
present in such compounds has been shown to be critical to their biological activities A new compound (Z)-
N_(4-dimethylamino) benzylidene) pyrimidine-2-aminewas synthesized by the reaction of 2-aminopyrimidine,
4-(dimethylamino) benzaldehyde and a drop of acetic acid in the presence of ethanol respectively. The chemical
structures of the synthesized compounds were characterised by using Fourier Transform Infra Red Spectroscopy
(FTIR), Proton Nuclear Magnetic Resonace Spectroscopy technique (1HNMR). The synthesized compound
showed mild antibacterial activity against Staphylococcus aureus and Escherichia coli.