Alzheimer's disease prediction using machine learning techniques and principal component analysis (PCA)

Alzheimer's disease (AD) is a neurodegenerative disease of the human brain that affects neurotransmitters, tissue, and neurons that impair the senses, memories, and behaviors. Still, now there is no remedy for Alzheimer's disease. Even so, prescribed drugs can help reduce the development of the disease. That's why Alzheimer's early detection is very essential for treatment, and further research. Very limited numbers of trained samples and the higher volume of feature descriptions are the major difficulties in early diagnosis of Alzheimer's disease using different classification strategies. In this article, we proposed and related Alzheimer's disease early diagnostic method using Mild Cognitive Impairment (MCI), Structural Magnetic Resonance (sMR) imaging for AD-discrimination and healthy control participants (HC) with Import Vector Machine (IVM), Regularized Extreme Learning Machine (RELM) and a Support vector machine (SVM).The greedy score-based strategy for choosing essential function vectors is used. Furthermore, a discriminatory, kernel-based method is taken to treat dynamic data transformations. For volume sMR scan image data from Alzheimer's disease neuroimaging initiative (ADNI) repositories, we compare the performance of these classification models. An ADNI datasets experimental study reveals that RELM can greatly enhance the accuracy for classification of AD from MCIs as well as HC individuals along with feature selection methodology.