Aromatic Plants as Potential Resources to Combat Osteoarthritis

Maring, Maphibanri and C., Balaji and M., Komala and Nandi, Sisir and S., Latha and H., Balaji Raghavendran (2024) Aromatic Plants as Potential Resources to Combat Osteoarthritis. Combinatorial Chemistry & High Throughput Screening, 27 (10). pp. 1434-1465. ISSN 13862073

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Abstract

Aromatic Plants as Potential Resources to Combat Osteoarthritis Maphibanri Maring https://orcid.org/0009-0009-6851-5725 Balaji C. https://orcid.org/0000-0002-1371-6345 Komala M. https://orcid.org/0000-0001-8357-535X Sisir Nandi https://orcid.org/0000-0002-9960-6584 Latha S. https://orcid.org/0000-0003-3730-8722 Balaji Raghavendran H. https://orcid.org/0000-0001-9374-7223 Abstract:

Osteoarthritis, which affects an estimated 10% of men and 18% of women over the age of 60 and is increasing in genetic prevalence and incidence, is acknowledged as the condition that degrades the quality of life for older adults in the world. There is currently no known treatment for osteoarthritis. The majority of therapeutic methods slow the progression of arthritis or treat its symptoms, making effective treatment to end the degenerative process of arthritis elusive. When non-pharmacological therapy is ineffective, various pharmacological therapies may be used to treat osteoarthritis. Pharmacological therapy, however, can have major adverse effects and be very expensive. As a result, alternative remedies have been researched. The promise for the safe and efficient management of osteoarthritis has been demonstrated by herbal remedies. Experimental research suggests that herbal extracts and compounds can reduce inflammation, inhibit catabolic processes, and promote anabolic processes that are important for treating osteoarthritis. Due to their therapeutic and innate pharmacological qualities, aromatic herbs are frequently employed as herbal remedies. Recent research has shown that aromatic plants have the potency to treat osteoarthritis. Additionally, complex mixtures of essential oils and their bioactive ingredients, which have anti-inflammatory and antioxidant properties and are obtained from aromatic plants, are frequently utilized as complementary therapies for osteoarthritis. To establish new study avenues, the advantageous anti-osteoarthritic effects of aromatic herbal medicines, including plants, essential oils, and their bioactive components, are extensively discussed.
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Int J Mol Sci 2021,22(5),2619 JAMA Katz J.N. 325 568 2021 10.1001/jama.2020.22171 Katz J.N.; Arant K.R.; Loeser R.F.; Diagnosis and treatment of hip and knee osteoarthritis. JAMA 2021,325(6),568-578 Medicina (Kaunas) Yunus M.H.M. 56 614 2020 10.3390/medicina56110614 Yunus M.H.M.; Nordin A.; Kamal H.; Pathophysiological perspective of osteoarthritis. Medicina (Kaunas) 2020,56(11),614 Complement Ther Clin Pract Nasiri A. 30 116 2018 10.1016/j.ctcp.2017.12.012 Nasiri A.; Mahmodi M.A.; Aromatherapy massage with lavender essential oil and the prevention of disability in ADL in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Complement Ther Clin Pract 2018,30(30),116-121 Complement Ther Clin Pract Barão Paixão V.L. 43 101391 2021 10.1016/j.ctcp.2021.101391 Barão Paixão V.L.; Freire de Carvalho J.; Essential oil therapy in rheumatic diseases: A systematic review. Complement Ther Clin Pract 2021,43,101391 Bone Res Chen D. 5 16044 2017 10.1038/boneres.2016.44 Chen D.; Shen J.; Zhao W.; Wang T.; Han L.; Hamilton J.L.; Im, H.J. Osteoarthritis: toward a comprehensive understanding of pathological mechanism. Bone Res 2017,5(1),16044 Drug Deliv Mao L. 28 1861 2021 10.1080/10717544.2021.1971798 Mao L.; Wu W.; Wang M.; Guo J.; Li H.; Zhang S.; Xu J.; Zou J.; Targeted treatment for osteoarthritis: drugs and delivery system. Drug Deliv 2021,28(1),1861-1876 Curr Signal Transduct Ther Ahmed T. 17 9 2022 Ahmed T.; Dey R.; Mukherjee J.; Samadder A.; Nandi S.; Age Related osteoarthritis: regenerative therapy, synthetic drugs, and naturopathy to combat abnormal signal transduction. Curr Signal Transduct Ther 2022,17(3),9-25 BMJ Hunter D.J. 332 639 2006 10.1136/bmj.332.7542.639 Hunter D.J.; Felson D.T.; Osteoarthritis. BMJ 2006,332(7542),639-642 Orthop Rev (Pavia) Steinmeyer J. 10 7782 2018 10.4081/or.2018.7782 Steinmeyer J.; Bock F.; Stöve J.; Jerosch J.; Flechtenmacher J.; Pharmacological treatment of knee osteoarthritis: Special considerations of the new German guideline. Orthop Rev (Pavia) 2018,10(4),7782 Clin Rheumatol Habib G.S. 28 749 2009 10.1007/s10067-009-1135-x Habib G.S.; Systemic effects of intra-articular corticosteroids. Clin Rheumatol 2009,28(7),749-756 Antioxidants Hahn D. 9 1191 2020 10.3390/antiox9121191 Hahn D.; Shin S.H.; Bae J.S.; Natural antioxidant and anti-inflammatory compounds in foodstuff or medicinal herbs inducing heme oxygenase-1 expression. Antioxidants 2020,9(12),1191 Pharmacogn Rev Petrovska B. 4 106 2010 10.4103/0973-7847.65321 Petrovska B.; Cekovska S.; Extracts from the history and medical properties of garlic. Pharmacogn Rev 2010,4(7),106-110 Nutrients Batiha G.E.S. 12 872 2020 10.3390/nu12030872 Batiha G.E.S.; Beshbishy A.M.; Wasef L.G.; Elewa Y.H.A.; Al-Sagan A.A.; El-Hack M.E.A.; Chemical constituents and pharmacological activities of garlic (Allium sativum L.): a review. Nutrients 2020,12(3),872 BMC Musculoskelet Disord Williams F.M.K. 11 280 2010 10.1186/1471-2474-11-280 Williams F.M.K.; Skinner J.; Spector T.D.; Cassidy A.; Clark I.M.; Davidson R.M.; MacGregor A.J.; Dietary garlic and hip osteoarthritis: evidence of a protective effect and putative mechanism of action. BMC Musculoskelet Disord 2010,11(1),280 Phytomedicine Dehghani S. 48 70 2018 10.1016/j.phymed.2018.04.060 Dehghani S.; Alipoor E.; Salimzadeh A.; Yaseri M.; Hosseini M.; Feinle-Bisset C.; Hosseinzadeh-Attar M.J.; The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis. Phytomedicine 2018,48,70-75 J Tradit Complement Med Hamidpour R. 3 221 2013 10.4103/2225-4110.119723 Hamidpour R.; Hamidpour S.; Hamidpour M.; Shahlari M.; Frankincense (rǔ xiāng; boswellia species): from the selection of traditional applications to the novel phytotherapy for the prevention and treatment of serious diseases. J Tradit Complement Med 2013,3(4),221-226 Phytother Res Blain E.J. 24 905 2010 10.1002/ptr.3055 Blain E.J.; Ali A.Y.; Duance V.C.; Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res 2010,24(6),905-912 Front Pharmacol Annaz H. 13 878749 2022 10.3389/fphar.2022.878749 Annaz H.; Sane Y.; Bitchagno G.T.M.; Ben Bakrim W.; Drissi B.; Mahdi I.; El Bouhssini M.; Sobeh M.; Caper (Capparis spinosa L.):an updated review on its phytochemistry, nutritional value, traditional uses, and therapeutic potential. Front Pharmacol 2022,13,878749 Nutrients Zhang H. 10 116 2018 10.3390/nu10020116 Zhang H.; Ma Z.; Phytochemical and pharmacological properties of Capparis spinosa as a medicinal plant. Nutrients 2018,10(2),116 J Ethnopharmacol Maresca M. 193 456 2016 10.1016/j.jep.2016.09.032 Maresca M.; Micheli L.; Di Cesare Mannelli L.; Tenci B.; Innocenti M.; Khatib M.; Mulinacci N.; Ghelardini C.; Acute effect of Capparis spinosa root extracts on rat articular pain. J Ethnopharmacol 2016,193,456-465 Int J Environ Res Public Health Wang X.Y. 18 7469 2021 10.3390/ijerph18147469 Wang X.Y.; Hao J.M.; Ren Q.R.; Li H.Y.; Wu J.S.; Zhu X.H.; Chen J.Y.; Wang Y.N.; Zhang L.S.; Cytotoxicity and apoptosis induced by Chenopodium ambrosioides L. Essential oil in human normal liver cell line L02via the endogenous mitochondrial pathway rather than the endoplasmic reticulum stress. Int J Environ Res Public Health 2021,18(14),7469 PLoS One Calado G.P. 10 e0141886 2015 10.1371/journal.pone.0141886 Calado G.P.; Lopes A.J.O.; Costa L.M.; Lima F.C.A.; Silva L.A.; Pereira W.S.; Amaral F.M.M.; Garcia J.B.S.; Cartágenes M.S.S.; Nascimento F.R.F.; Chenopodium ambrosioides L. Reduces synovial inflammation and pain in experimental osteoarthritis. PLoS One 2015,10(11),e0141886 J Tradit Complement Med Bellamkonda R. 8 203 2018 10.1016/j.jtcme.2017.05.007 Bellamkonda R.; Karuna R.; Sasi Bhusana Rao B.; Haritha K.; Manjunatha B.; Silpa S.; Saralakumari D.; Beneficiary effect of Commiphora mukul ethanolic extract against high fructose diet induced abnormalities in carbohydrate and lipid metabolism in wistar rats. J Tradit Complement Med 2018,8(1),203-211 Phytother Res Shah R. 26 1594 2012 10.1002/ptr.4647 Shah R.; Gulati V.; Palombo E.A.; Pharmacological properties of guggulsterones, the major active components of gum guggul. Phytother Res 2012,26(11),1594-1605 Avicenna J Phytomed Sotoudeh R. 9 454 2019 Sotoudeh R.; Hadjzadeh M.A.R.; Gholamnezhad Z.; Aghaei A.; The anti-diabetic and antioxidant effects of a combination of Commiphora mukul, Commiphora myrrha and Terminalia chebula in diabetic rats. Avicenna J Phytomed 2019,9(5),454-464 Altern Ther Health Med Singh B.B. 9 74 2003 Singh B.B.; Mishra L.C.; Vinjamury S.P.; Aquilina N.; Singh V.J.; Shepard N.; The effectiveness of Commiphora mukul for osteoarthritis of the knee: an outcomes study. Altern Ther Health Med 2003,9(3),74-79 Nutrients Micheli L. 12 1618 2020 10.3390/nu12061618 Micheli L.; Di Cesare Mannelli L.; Mattoli L.; Tamimi S.; Flamini E.; Garetto S.; Lucci J.; Giovagnoni E.; Cinci L.; D’Ambrosio M.; Luceri C.; Ghelardini C.; Intra-articular route for the system of molecules 14G1862 from Centella asiatica: pain relieving and protective effects in a rat model of osteoarthritis. Nutrients 2020,12(6),1618 Front Pharmacol Sun B. 11 568032 2020 10.3389/fphar.2020.568032 Sun B.; Wu L.; Wu Y.; Zhang C.; Qin L.; Hayashi M.; Kudo M.; Gao M.; Liu T.; Therapeutic potential of Centella asiatica and its triterpenes: a review. Front Pharmacol 2020,11,568032 Front Pharmacol Wong J.H. 12 687935 2021 10.3389/fphar.2021.687935 Wong J.H.; Barron A.M.; Abdullah, JM Mitoprotective effects of Centella asiatica (L.) Urb.: Anti-inflammatory and neuroprotective opportunities in neurodegenerative disease. Front Pharmacol 2021,12,687935 J Appl Oral Sci Rotpenpian N. 29 e20210329 2021 10.1590/1678-7757-2021-0329 Rotpenpian N.; Arayapisit T.; Roumwong A.; Pakaprot N.; Tantisira M.; Wanasuntronwong A.; A standardized extract of Centella asiatica (ECa 233) prevents temporomandibular joint osteoarthritis by modulating the expression of local inflammatory mediators in mice. J Appl Oral Sci 2021,29,e20210329 Front Pharmacol Syamsunarno M.R.A.A. 12 725745 2021 10.3389/fphar.2021.725745 Syamsunarno M.R.A.A.; Safitri R.; Kamisah Y.; Protective effects of Caesalpinia sappan Linn. and its bioactive compounds on cardiovascular organs. Front Pharmacol 2021,12,725745 J Ethnopharmacol Wu S.Q. 138 364 2011 10.1016/j.jep.2011.09.011 Wu S.Q.; Otero M.; Unger F.M.; Goldring M.B.; Phrutivorapongkul A.; Chiari C.; Kolb A.; Viernstein H.; Toegel S.; Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages. J Ethnopharmacol 2011,138(2),364-372 Genes Nutr Toegel S. 7 307 2012 10.1007/s12263-011-0244-8 Toegel S.; Wu S.Q.; Otero M.; Goldring M.B.; Leelapornpisid P.; Chiari C.; Kolb A.; Unger F.M.; Windhager R.; Viernstein H.; Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes. Genes Nutr 2012,7(2),307-318 Acta Pharm Abdel-Lateef E. 66 387 2016 10.1515/acph-2016-0028 Abdel-Lateef E.; Mahmoud F.; Hammam O.; El-Ahwany E.; El-Wakil E.; Kandil S.; Abu Taleb H.; El-Sayed M.; Hassenein H.; Bioactive chemical constituents of Curcuma longa L. rhizomes extract inhibit the growth of human hepatoma cell line (HepG2). Acta Pharm 2016,66(3),387-398 Ann Intern Med Wang Z. 173 861 2020 10.7326/M20-0990 Wang Z.; Jones G.; Winzenberg T.; Cai G.; Laslett L.L.; Aitken D.; Hopper I.; Singh A.; Jones R.; Fripp J.; Ding C.; Antony B.; Effectiveness of Curcuma longa extract for the treatment of symptoms and effusion-synovitis of knee osteoarthritis. Ann Intern Med 2020,173(11),861-869 Arthritis Res Ther Henrotin Y. 21 179 2019 10.1186/s13075-019-1960-5 Henrotin Y.; Malaise M.; Wittoek R.; de Vlam K.; Brasseur J.P.; Luyten F.P.; Jiangang Q.; Van den Berghe M.; Uhoda R.; Bentin J.; De Vroey T.; Erpicum L.; Donneau A.F.; Dierckxsens Y.; Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res Ther 2019,21(1),179 Molecules Gxaba N. 27 3637 2022 10.3390/molecules27113637 Gxaba N.; Manganyi M.C.; The Fight against Infection and Pain: Devil’s Claw (Harpagophytum procumbens) a rich source of anti-inflammatory activity: 2011–2022. Molecules 2022,27(11),3637 Nutrients Mariano A. 12 2545 2020 10.3390/nu12092545 Mariano A.; Di Sotto A.; Leopizzi M.; Garzoli S.; Di Maio V.; Gullì M.; Dalla Vedova P.; Ammendola S.; Scotto d’Abusco A.; Antiarthritic effects of a root extract from Harpagophytum procumbens DC: novel insights into the molecular mechanisms and possible bioactive phytochemicals. Nutrients 2020,12(9),2545 Phytother Res Menghini L. 33 2152 2019 10.1002/ptr.6395 Menghini L.; Recinella L.; Leone S.; Chiavaroli A.; Cicala C.; Brunetti L.; Vladimir-Knežević S.; Orlando, G.; Ferrante, C. Devil’s claw (Harpagophytum procumbens) and chronic inflammatory diseases: A concise overview on preclinical and clinical data. Phytother Res 2019,33(9),2152-2162 Pharmaceuticals (Basel) Mariano A. 15 457 2022 10.3390/ph15040457 Mariano A.; Bigioni I.; Mattioli R.; Di Sotto A.; Leopizzi M.; Garzoli S.; Mariani P.F.; Dalla Vedova P.; Ammendola S.; Scotto d’Abusco A.; Harpagophytum procumbens root extract mediates anti-inflammatory effects in osteoarthritis synoviocytes through CB2 activation. Pharmaceuticals (Basel) 2022,15(4),457 Plants Paparella A. 11 1209 2022 10.3390/plants11091209 Paparella A.; Nawade B.; Shaltiel-Harpaz L.; Ibdah M.; A review of the botany, volatile composition, biochemical and molecular aspects, and traditional uses of Laurus nobilis. Plants 2022,11(9),1209 Biomed Sci Maghsoudi H. 8 10 2022 10.11648/j.bs.20220801.13 Maghsoudi H.; Khosrogardi M.; Akbarnejad Eshkalak A.; Tatar Mamaghani Y.; Bakhshi Khanaki G.; Yazdanpanah E.; The effect of the alcoholic essence of Laurus nobilis L. on pro-inflammatory cytokine gene expression in synoviocytes and macrophage/monocyte. Biomed Sci 2022,8(1),10-19 Pharmacol Ther Zhang L. 207 107452 2020 10.1016/j.pharmthera.2019.107452 Zhang L.; Wei W.; Anti-inflammatory and immunoregulatory effects of paeoniflorin and total glucosides of paeony. Pharmacol Ther 2020,207,107452 Biomed Pharmacother Zhou Y.X. 130 110505 2020 10.1016/j.biopha.2020.110505 Zhou Y.X.; Gong X.H.; Zhang H.; Peng C.; A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomed Pharmacother 2020,130,110505 Front Pharmacol Liang S.B. 13 904657 2022 10.3389/fphar.2022.904657 Liang S.B.; Cao H.J.; Kong L.Y.; Wei J.L.; Robinson N.; Yang S.H.; Zhu S.J.; Li Y.Q.; Fei Y.T.; Han M.; Liu J.P.; Systematic review and meta-analysis of Chinese herbal formula Tongxie Yaofang for diarrhea-predominant irritable bowel syndrome: Evidence for clinical practice and future trials. Front Pharmacol 2022,13,904657 Medicine (Baltimore) Lee D. 99 e20907 2020 10.1097/MD.0000000000020907 Lee D.; Kim S.J.; Kim H.A.; 12 week, randomized, double-blind, placebo-controlled clinical trial for the evaluation of the efficacy and safety of HT083 on mild osteoarthritis. Medicine (Baltimore) 2020,99(28),e20907 Pharmacol Res Liu H. 161 105263 2020 10.1016/j.phrs.2020.105263 Liu H.; Lu X.; Hu Y.; Fan X.; Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy. Pharmacol Res 2020,161,105263 Molecules Xie W. 23 940 2018 10.3390/molecules23040940 Xie W.; Meng X.; Zhai Y.; Zhou P.; Ye T.; Wang Z.; Sun G.; Sun X.; Panax notoginseng saponins: a review of its mechanisms of antidepressant or anxiolytic effects and network analysis on phytochemistry and pharmacology. Molecules 2018,23(4),940 Int J Mol Med Zhang Y. 45 1225 2020 Zhang Y.; Cai W.; Han G.; Zhou S.; Li J.; Chen M.; Li H.; Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K AKT mTOR pathway in osteoarthritic chondrocytes. Int J Mol Med 2020,45(4),1225-1236 Biomed Pharmacother Ju L. 129 110471 2020 10.1016/j.biopha.2020.110471 Ju L.; Hu P.; Chen P.; Xue X.; Li Z.; He F.; Qiu Z.; Cheng J.; Huang F.; Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/Akt/NF-κB pathway. Biomed Pharmacother 2020,129,110471 Front Pharmacol Jantan I. 10 878 2019 10.3389/fphar.2019.00878 Jantan I.; Haque M.A.; Ilangkovan M.; Arshad L.; An insight into the modulatory effects and mechanisms of action of Phyllanthus species and their bioactive metabolites on the immune system. Front Pharmacol 2019,10,878 Chem Biodivers Qi W. 11 364 2014 10.1002/cbdv.201200244 Qi W.; Hua L.; Gao K.; Chemical constituents of the plants from the genus Phyllanthus. Chem Biodivers 2014,11(3),364-395 J Bodyw Mov Ther Pinkaew D. 24 15 2020 10.1016/j.jbmt.2019.04.013 Pinkaew D.; Kiattisin K.; Wonglangka K.; Awoot P.; Phonophoresis of Phyllanthus amarus nanoparticle gel improves functional capacity in individuals with knee osteoarthritis: A randomized controlled trial. J Bodyw Mov Ther 2020,24(1),15-18 Planta Med Buddhachat K. 83 87 2017 Buddhachat K.; Chomdej S.; Pradit W.; Nganvongpanit K.; Ongchai S.; In vitro chondroprotective potential of extracts obtained from various Phyllantus Species. Planta Med 2017,83(1-02),87-96 Ayu Perera P. 35 411 2014 10.4103/0974-8520.159007 Perera P.; Perera M.; Kumarasinghe N.; Effect of Sri Lankan traditional medicine and Ayurveda on Sandhigata Vata (osteoarthritis of knee joint). Ayu 2014,35(4),411-415 Molecules Salehi B. 24 1364 2019 10.3390/molecules24071364 Salehi B.; Zakaria Z.A.; Gyawali R.; Ibrahim S.A.; Rajkovic J.; Shinwari Z.K.; Khan T.; Sharifi-Rad J.; Ozleyen A.; Turkdonmez E.; Valussi M.; Tumer T.B.; Monzote Fidalgo L.; Martorell M.; Setzer W.N.; Piper species: a comprehensive review on their phytochemistry, biological activities and applications. Molecules 2019,24(7),1364 Int J Adv Res (Indore) Nirmal P.S. 3 480 2015 Nirmal P.S.; Jagtap S.D.; Devarshi P.P.; Narkhede A.N.; Koppikar S.J.; Ingale D.R.; Cartilage protective effect of Sida cordifolia L. and Piper longum L. is through modulation of MMPs and TIMP. Int J Adv Res (Indore) 2015,3(11),480-488 Molecules Igual M. 27 4737 2022 10.3390/molecules27154737 Igual M.; García-Herrera P.; Cámara R.M.; Martínez-Monzó J.; García-Segovia P.; Cámara M.; Bioactive compounds in rosehip (Rosa canina) powder with encapsulating agents. Molecules 2022,27(15),4737 Curr Pharm Des Ayati Z. 24 4101 2019 10.2174/1381612824666181010151849 Ayati Z.; Amiri M.S.; Ramezani M.; Delshad E.; Sahebkar A.; Emami S.A.; Phytochemistry, traditional uses and pharmacological profile of rose hip: a review. Curr Pharm Des 2019,24(35),4101-4124 Mediators Inflamm Schwager J. 2014 1 2014 10.1155/2014/105710 Schwager J.; Richard N.; Schoop R.; Wolfram S.; A novel rose hip preparation with enhanced anti-inflammatory and chondroprotective effects. Mediators Inflamm 2014,2014,1-10 Phytomedicine Jia Q. 58 152871 2019 10.1016/j.phymed.2019.152871 Jia Q.; Zhu R.; Tian Y.; Chen B.; Li R.; Li L.; Wang L.; Che Y.; Zhao D.; Mo F.; Gao S.; Zhang D.; Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety. Phytomedicine 2019,58,152871 Antioxidants Jung I. 9 857 2020 10.3390/antiox9090857 Jung I.; Kim H.; Moon S.; Lee H.; Kim B.; Overview of Salvia miltiorrhiza as a potential therapeutic agent for various diseases: an update on efficacy and mechanisms of action. Antioxidants 2020,9(9),857 Exp Anim Xu X. 67 127 2018 10.1538/expanim.17-0062 Xu X.; Lv H.; Li X.; Su H.; Zhang X.; Yang J.; Danshen attenuates cartilage injuries in osteoarthritis in vivo and in vitro by activating JAK2/STAT3 and AKT pathways. Exp Anim 2018,67(2),127-137 Biochem Cell Biol Xu X. 95 644 2017 10.1139/bcb-2017-0025 Xu X.; Lv H.; Li X.; Su H.; Zhang X.; Yang J.; Danshen attenuates osteoarthritis-related cartilage degeneration through inhibition of NF-κB signaling pathway in vivo and in vitro. Biochem Cell Biol 2017,95(6),644-651 J Diet Suppl Mandlik Ingawale D.S. 18 183 2021 10.1080/19390211.2020.1741484 Mandlik Ingawale D.S.; Namdeo A.G.; Pharmacological evaluation of Ashwagandha highlighting its healthcare claims, safety, and toxicity aspects. J Diet Suppl 2021,18(2),183-226 Adv Exp Med Biol White P.T. 928 329 2016 10.1007/978-3-319-41334-1_14 White P.T.; Subramanian C.; Motiwala H.F.; Cohen M.S.; Natural withanolides in the treatment of chronic diseases. Adv Exp Med Biol 2016,928,329-373 J Ayurveda Integr Med Ramakanth G.S.H. 7 151 2016 10.1016/j.jaim.2016.05.003 Ramakanth G.S.H.; Uday Kumar C.; Kishan P.V.; Usharani P.; A randomized, double blind placebo controlled study of efficacy and tolerability of Withaina somnifera extracts in knee joint pain. J Ayurveda Integr Med 2016,7(3),151-157 Appl Biochem Biotechnol Ganesan K. 165 1075 2011 10.1007/s12010-011-9326-8 Ganesan K.; Sehgal P.K.; Mandal A.B.; Sayeed S.; Protective effect of Withania somnifera and Cardiospermum halicacabum extracts against collagenolytic degradation of collagen. Appl Biochem Biotechnol 2011,165(3-4),1075-1091 Foods Mao Q.Q. 8 185 2019 10.3390/foods8060185 Mao Q.Q.; Xu X.Y.; Cao S.Y.; Gan R.Y.; Corke H.; Beta T.; Li H.B.; Bioactive compounds and bioactivities of ginger (Zingiber officinale roscoe). Foods 2019,8(6),185 BMC Complement Altern Med Aborehab N.M. 17 495 2017 10.1186/s12906-017-2002-y Aborehab N.M.; El Bishbishy M.H.; Refaiy A.; Waly N.E.; A putative Chondroprotective role for IL-1β and MPO in herbal treatment of experimental osteoarthritis. BMC Complement Altern Med 2017,17(1),495 J Nutr Gerontol Geriatr Mozaffari-Khosravi H. 35 209 2016 10.1080/21551197.2016.1206762 Mozaffari-Khosravi H.; Naderi Z.; Dehghan A.; Nadjarzadeh A.; Fallah Huseini H.; Effect of ginger supplementation on proinflammatory cytokines in older patients with osteoarthritis: outcomes of a randomized controlled clinical trial. J Nutr Gerontol Geriatr 2016,35(3),209-218 Electron Physician Kooshki A. 8 3193 2016 10.19082/3193 Kooshki A.; Forouzan R.; Rakhshani M.H.; Mohammadi M.; Effect of topical application of Nigella Sativa Oil and oral acetaminophen on pain in elderly with knee osteoarthritis: a crossover clinical trial. Electron Physician 2016,8(11),3193-3197 Complement Ther Clin Pract Tuna H.I. 31 290 2018 10.1016/j.ctcp.2018.03.013 Tuna H.I.; Babadag B.; Ozkaraman A.; Balci Alparslan G.; Investigation of the effect of black cumin oil on pain in osteoarthritis geriatric individuals. Complement Ther Clin Pract 2018,31,290-294 J Musculoskelet Neuronal Interact Turhan Y. 19 362 2019 Turhan Y.; Arıcan, M.; Karaduman, Z.O.; Turhal, O.; Gamsızkan, M.; Aydın, D.; Kılıç, B.; Özkan, K. Chondroprotective effect of Nigella sativa oil in the early stages of osteoarthritis: an experimental study in rabbits. J Musculoskelet Neuronal Interact 2019,19(3),362-369 Complement Ther Clin Pract Huseini H.F. 49 101666 2022 10.1016/j.ctcp.2022.101666 Huseini H.F.; Mohtashami R.; Sadeghzadeh E.; Shadmanfar S.; Hashem-Dabaghian F.; Kianbakht S.; Efficacy and safety of oral Nigella sativa oil for symptomatic treatment of knee osteoarthritis: A double-blind, randomized, placebo-controlled clinical trial. Complement Ther Clin Pract 2022,49,101666 Phytother Res Diefenbach A.L. 32 586 2018 10.1002/ptr.5992 Diefenbach A.L.; Muniz F.W.M.G.; Oballe H.J.R.; Rösing C.K.; Antimicrobial activity of copaiba oil (Copaifera ssp.) on oral pathogens: Systematic review. Phytother Res 2018,32(4),586-596 Complement Ther Clin Pract Bahr T. 33 170 2018 10.1016/j.ctcp.2018.10.004 Bahr T.; Allred K.; Martinez D.; Rodriguez D.; Winterton P.; Effects of a massage-like essential oil application procedure using Copaiba and Deep Blue oils in individuals with hand arthritis. Complement Ther Clin Pract 2018,33,170-176 J Chromatogr Sci Xavier-Junior F.H. 55 969 2017 10.1093/chromsci/bmx065 Xavier-Junior F.H.; Maciuk A.; Rochelle do Vale Morais A.; Alencar E.N.; Garcia V.L.; Tabosa do Egito E.S.; Vauthier C.; Development of a gas chromatography method for the analysis of copaiba oil. J Chromatogr Sci 2017,55(10),969-978 J Pharm Biomed Anal Cavaleiro C. 54 619 2011 10.1016/j.jpba.2010.09.039 Cavaleiro C.; Gonçalves M.J.; Serra D.; Santoro G.; Tomi F.; Bighelli A.; Salgueiro L.; Casanova J.; Composition of a volatile extract of Eryngium duriaei subsp. juresianum (M. Laínz) M. Laínz, signalised by the antifungal activity. J Pharm Biomed Anal 2011,54(3),619-622 Plant Syst Evol Tavares A.C. 299 611 2013 10.1007/s00606-012-0747-9 Tavares A.C.; Loureiro J.; Cavaleiro C.; Salgueiro L.; Canhoto J.M.; Paiva J.; Characterization and distinction of two subspecies of Eryngium duriaei J. Gay ex Boiss., an Iberian endemic Apiaceae, using flow cytometry and essential oils composition. Plant Syst Evol 2013,299(3),611-618 Osteoarthritis Cartilage Rufino A.T. 20 S290 2012 10.1016/j.joca.2012.02.502 Rufino A.T.; Cavaleiro C.; Judas F.; Salgueiro L.; Lopes M.C.; Mendes A.F.; The essential oil of Eryngium duriaei subsp. juresianum inhibits IL-1β induced NF-kB and MAPK activation in human chondrocytes. Osteoarthritis Cartilage 2012,20,S290 Trad Integr Med Zahra Emami-Razavi S. 1 101 2016 Zahra Emami-Razavi S.; Khamessi M.; Forough B.; Karimi M.; Mansoori K.; Sajadi S.; Effects of galbanum oil on patients with knee osteoarthritis: a randomized controlled clinical. Trad Integr Med 2016,1(3),101-107 Front Pharmacol Sonigra P. 11 608649 2021 10.3389/fphar.2020.608649 Sonigra P.; Meena M.; Metabolic profile, bioactivities, and variations in the chemical constituents of essential oils of the Ferula genus (Apiaceae). Front Pharmacol 2021,11,608649 Molecules Wang X. 25 3955 2020 10.3390/molecules25173955 Wang X.; Shen Y.; Thakur K.; Han J.; Zhang J.G.; Hu F.; Wei Z.J.; Antibacterial activity and mechanism of ginger essential oil against Escherichia coli and Staphylococcus aureus. Molecules 2020,25(17),3955 Indian J Physiol Pharmacol Jeena K. 57 51 2013 Jeena K.; Liju V.B.; Kuttan R.; Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger. Indian J Physiol Pharmacol 2013,57(1),51-62 Res Theory Nurs Pract Tosun B. 31 379 2017 10.1891/1541-6577.31.4.379 Tosun B.; Unal N.; Yigit D.; Can N.; Aslan O.; Tunay S.; Effects of self-knee massage with ginger oil in patients with osteoarthritis: an experimental study. Res Theory Nurs Pract 2017,31(4),379-392 Dermatitis de Groot A. 27 325 2016 10.1097/DER.0000000000000218 de Groot A.; Schmidt E.; Essential Oils, Part V: peppermint oil, lavender oil, and lemongrass oil. Dermatitis 2016,27(6),325-332 Molecules 24 3270 2019 10.3390/molecules24183270 Białoń M.; Krzyśko-Łupicka, T.; Nowakowska-Bogdan, E.; Wieczorek, P.P. Chemical composition of two different lavender essential oils and their effect on facial skin microbiota. Molecules 2019,24(18),3270 An Acad Bras Cienc Silva G.L.D. 87 1397 2015 10.1590/0001-3765201520150056 Silva G.L.D.; Luft C.; Lunardelli A.; Amaral R.H.; Melo D.A.D.S.; Donadio M.F.; Nunes F.B.; Azambuja M.S.D.; Santana J.C.; Moraes C.M.B.; Mello R.O.; Cassel E.; Pereira M.A.D.A.; Oliveira J.R.D.; Antioxidant, analgesic and anti-inflammatory effects of lavender essential oil. An Acad Bras Cienc 2015,87(2)(Suppl.),1397-1408 Complement Ther Clin Pract Nasiri A. 25 75 2016 10.1016/j.ctcp.2016.08.002 Nasiri A.; Mahmodi M.A.; Nobakht Z.; Effect of aromatherapy massage with lavender essential oil on pain in patients with osteoarthritis of the knee: A randomized controlled clinical trial. Complement Ther Clin Pract 2016,25,75-80 J Ethnopharmacol Rodríguez-Chávez J.L. 195 39 2017 10.1016/j.jep.2016.11.021 Rodríguez-Chávez J.L.; Egas V.; Linares E.; Bye R.; Hernández T.; Espinosa-García F.J.; Delgado G.; Mexican Arnica (Heterotheca inuloides Cass. Asteraceae: Astereae): Ethnomedical uses, chemical constituents and biological properties. J Ethnopharmacol 2017,195,39-63 Nat Prod Res Martin D.F-S. 27 2347 2013 10.1080/14786419.2013.828289 Martin D.F-S.; Perea-Flores M.J.; Morales-López J.; Centeno-Alvarez M.M.; Pérez-Ishiwara G.; Pérez-Hernández N.; Pérez-Hernández E.; Effect of Heterotheca inuloides essential oil on rat cytoskeleton articular chondrocytes. Nat Prod Res 2013,27(24),2347-2350 J Clin Exp Dent Shetty S.B. 8 0 2016 10.4317/jced.52493 Shetty S.B.; Mahin-Syed-Ismail P.; Varghese S.; Thomas-George B.; Antimicrobial effects of Citrus sinensis peel extracts against dental caries bacteria: An in vitro study. J Clin Exp Dent Kandathil- Thajuraj, P.; Baby, D.; Haleem, S.; Sreedhar, S.; Devang-Divakar, D 2016,8(1),0 Evid Based Complement Alternat Med Mannucci C. 2018 1 2018 10.1155/2018/3624094 Mannucci C.; Calapai F.; Cardia L.; Inferrera G.; D’Arena G.; Di Pietro M.; Navarra M.; Gangemi S.; Ventura Spagnolo E.; Calapai G.; Clinical pharmacology of Citrus aurantium and Citrus sinensis for the treatment of anxiety. Evid Based Complement Alternat Med 2018,2018,1-18 Molecules Torres-Alvarez C. 25 5109 2020 10.3390/molecules25215109 Torres-Alvarez C.; Castillo S.; Sánchez-García E.; Aguilera González C.; Galindo-Rodríguez S.A.; Gabaldón-Hernández J.A.; Báez-González J.G.; Inclusion complexes of concentrated orange oils and β-cyclodextrin: physicochemical and biological characterizations. Molecules 2020,25(21),5109 Indian J Palliat Care Hekmatpou D. 23 431 2017 10.4103/IJPC.IJPC_37_17 Hekmatpou D.; Pourandish Y.; Farahani P.; Parvizrad R.; The effect of aromatherapy with the essential oil of orange on pain and vital signs of patients with fractured limbs admitted to the emergency ward: A randomized clinical trial. Indian J Palliat Care 2017,23(4),431-436 Phytochemistry Kamatou G.P.P. 96 15 2013 10.1016/j.phytochem.2013.08.005 Kamatou G.P.P.; Vermaak I.; Viljoen A.M.; Lawrence B.M.; Menthol: A simple monoterpene with remarkable biological properties. Phytochemistry 2013,96,15-25 BMC Compl Med Ther Mohammadifar M. 21 57 2021 10.1186/s12906-021-03236-y Mohammadifar M.; Aarabi M.H.; Aghighi F.; Kazemi M.; Vakili Z.; Memarzadeh M.R.; Talaei S.A.; Anti-osteoarthritis potential of peppermint and rosemary essential oils in a nanoemulsion form: behavioral, biochemical, and histopathological evidence. BMC Compl Med Ther 2021,21(1),57 Iran J Basic Med Sci Ghasemzadeh Rahbardar M. 23 1100 2020 Ghasemzadeh Rahbardar M.; Hosseinzadeh H.; Therapeutic effects of rosemary (Rosmarinus officinalis L.) and its active constituents on nervous system disorders. Iran J Basic Med Sci 2020,23(9),1100-1112 BMC Complement Altern Med 14 225 2014 10.1186/1472-6882-14-225 Rašković A.; Milanović I.; Pavlović N.; Ćebović T.; Vukmirović S.; Mikov, M. Antioxidant activity of rosemary (Rosmarinus officinalis L.) essential oil and its hepatoprotective potential. BMC Complement Altern Med 2014,14(1),225 Ulum-i Daruyi Belkhodja H. 23 12 2017 10.15171/PS.2017.03 Belkhodja H.; Meddah B.; Meddah TirTouil, A.; Slimani, K.; Tou, A. Radiographic and histopathologic analysis on osteoarthritis rat model treated with essential oils of Rosmarinus officinalis and Populus Alba. Ulum-i Daruyi 2017,23(1),12-17 Jpn J Nurs Sci Pehlivan S. 16 450 2019 10.1111/jjns.12254 Pehlivan S.; Karadakovan A.; Effects of aromatherapy massage on pain, functional state, and quality of life in an elderly individual with knee osteoarthritis. Jpn J Nurs Sci 2019,16(4),450-458 DNA Res Qiu D. 26 423 2019 10.1093/dnares/dsz020 Qiu D.; Bai S.; Ma J.; Zhang L.; Shao F.; Zhang K.; Yang Y.; Sun T.; Huang J.; Zhou Y.; Galbraith D.W.; Wang Z.; Sun G.; The genome of Populus alba x Populus tremula var. glandulosa clone 84K. DNA Res 2019,26(5),423-431 Chem Biodivers 18 e2100227 2021 10.1002/cbdv.202100227 Pobłocka-Olech, L.; Głód, D.; Jesionek, A.; Łuczkiewicz, M.; Krauze-Baranowska, M. Studies on the polyphenolic composition and the antioxidant properties of the leaves of poplar (populus spp.) various species and hybrids. Chem Biodivers 2021,18(7),e2100227 Molecules Tawfeek N. 24 1999 2019 10.3390/molecules24101999 Tawfeek N.; Sobeh M.; Hamdan D.I.; Farrag N.; Roxo M.; El-Shazly A.M.; Wink M.; Phenolic compounds from Populus alba L. and Salix subserrataWilld. (Salicaceae) counteract oxidative stress in Caenorhabditis elegans. Molecules 2019,24(10),1999 Phytochemistry Allenspach M. 190 112857 2021 10.1016/j.phytochem.2021.112857 Allenspach M.; Steuer, C. α-Pinene: A never-ending story. Phytochemistry 2021,190,112857 Biomolecules Salehi B. 9 738 2019 10.3390/biom9110738 Salehi B.; Upadhyay S.; Erdogan Orhan I.; Kumar Jugran A.; L.D. Jayaweera; S.; A Dias, D.; Sharopov, F.; Taheri, Y.; Martins, N.; Baghalpour, N.; Cho, W.C.; Sharifi-Rad, J. Therapeutic potential of α-and β-pinene: a miracle gift of nature. Biomolecules 2019,9(11),738 J Nat Prod Rufino A.T. 77 264 2014 10.1021/np400828x Rufino A.T.; Ribeiro M.; Judas F.; Salgueiro L.; Lopes M.C.; Cavaleiro C.; Mendes A.F.; Anti-inflammatory and chondroprotective activity of (+)-α-pinene: structural and enantiomeric selectivity. J Nat Prod 2014,77(2),264-269 Cancer Med Fidyt K. 5 3007 2016 10.1002/cam4.816 Fidyt K.; Fiedorowicz A.; Strządała, L.; Szumny, A. β -caryophyllene and β -caryophyllene oxide-natural compounds of anticancer and analgesic properties. Cancer Med 2016,5(10),3007-3017 Nutrients Scandiffio R. 12 3273 2020 10.3390/nu12113273 Scandiffio R.; Geddo F.; Cottone E.; Querio G.; Antoniotti S.; Gallo M.P.; Maffei M.E.; Bovolin P.; Protective effects of (E)-β-caryophyllene (BCP) in chronic inflammation. Nutrients 2020,12(11),3273 Neuropharmacology Mlost J. 204 108908 2022 10.1016/j.neuropharm.2021.108908 Mlost J.; Kac P.; Kędziora, M.; Starowicz, K. Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development. Neuropharmacology 2022,204,108908 Pharmaceuticals (Basel) Mattiuzzo E. 14 286 2021 10.3390/ph14030286 Mattiuzzo E.; Faggian A.; Venerando R.; Benetti A.; Belluzzi E.; Abatangelo G.; Ruggieri P.; Brun P.; In vitro effects of low doses of β-caryophyllene, ascorbic acid and d-glucosamine on human chondrocyte viability and inflammation. Pharmaceuticals (Basel) 2021,14(3),286 Food Sci Nutr Imran M. 10 3544 2022 10.1002/fsn3.2994 Imran M.; Aslam M.; Alsagaby S.A.; Saeed F.; Ahmad I.; Afzaal M.; Arshad M.U.; Abdelgawad M.A.; El-Ghorab A.H.; Khames A.; Shariati M.A.; Ahmad A.; Hussain M.; Imran A.; Islam S.; Therapeutic application of carvacrol: A comprehensive review. Food Sci Nutr 2022,10(11),3544-3561 Phytother Res Sharifi-Rad M. 32 1675 2018 10.1002/ptr.6103 Sharifi-Rad M.; Varoni E.M.; Iriti M.; Martorell M.; Setzer W.N.; del Mar Contreras M.; Salehi B.; Soltani-Nejad A.; Rajabi S.; Tajbakhsh M.; Sharifi-Rad J.; Carvacrol and human health: A comprehensive review. Phytother Res 2018,32(9),1675-1687 Mol Med Rep Xiao Y. 17 3987 2018 Xiao Y.; Li B.; Liu J.; Ma X.; Carvacrol ameliorates inflammatory response in interleukin 1β-stimulated human chondrocytes. Mol Med Rep 2018,17(3),3987-3992 Antibiotics (Basel) Usai F. 12 254 2023 10.3390/antibiotics12020254 Usai F.; Di Sotto A.; Trans-cinnamaldehyde as a novel candidate to overcome bacterial resistance: an overview of in vitro studies. Antibiotics (Basel) 2023,12(2),254 Pharmacol Res Zhu R. 122 78 2017 10.1016/j.phrs.2017.05.019 Zhu R.; Liu H.; Liu C.; Wang L.; Ma R.; Chen B.; Li L.; Niu J.; Fu M.; Zhang D.; Gao S.; Cinnamaldehyde in diabetes: A review of pharmacology, pharmacokinetics and safety. Pharmacol Res 2017,122,78-89 BioMed Res Int Xia T. 2019 1 2019 10.1155/2019/4039472 Xia T.; Gao R.; Zhou G.; Liu J.; Li J.; Shen J.; Trans-cinnamaldehyde inhibits IL-1β-stimulated inflammation in chondrocytes by suppressing NF-κB and p38-JNK pathways and exerts chondrocyte protective effects in a rat model of osteoarthritis. BioMed Res Int 2019,2019,1-12 Int Immunopharmacol Atabaki M. 85 106607 2020 10.1016/j.intimp.2020.106607 Atabaki M.; Shariati-Sarabi Z.; Tavakkol-Afshari J.; Mohammadi M.; Significant immunomodulatory properties of curcumin in patients with osteoarthritis; a successful clinical trial in Iran. Int Immunopharmacol 2020,85,106607 BMC Compl Med Ther Jamali N. 20 305 2020 10.1186/s12906-020-03105-0 Jamali N.; Adib-Hajbaghery M.; Soleimani A.; The effect of curcumin ointment on knee pain in older adults with osteoarthritis: a randomized placebo trial. BMC Compl Med Ther 2020,20(1),305 Pharmacogn Mag Velusami C.C. 13 623 2017 10.4103/pm.pm_465_16 Velusami C.C.; Bethapudi B.; Murugan S.; Illuri R.; Mundkinajeddu D.; Bioactive turmerosaccharides from Curcuma longa Extract (NR-INF-02): Potential ameliorating effect on osteoarthritis pain. Pharmacogn Mag 2017,13(51)(Suppl. 3),623 Altern Ther Health Med Yuan T. 28 28 2022 Yuan T.; Cai D.; Hu B.; Zhu Y.; Qin J.; Therapeutic effects of curcumin on osteoarthritis and its protection of chondrocytes through the WNT/β-catenin signaling pathway. Altern Ther Health Med 2022,28(5),28-37 Front Pharmacol Mitra S. 13 943967 2022 10.3389/fphar.2022.943967 Mitra S.; Das R.; Emran T.B.; Labib R.K.; Noor-E-Tabassum; Islam, F.; Sharma, R.; Ahmad, I.; Nainu, F.; Chidambaram, K.; Alhumaydhi, F.A.; Chandran, D.; Capasso, R.; Wilairatana, P. Diallyl disulfide: a bioactive garlic compound with anticancer potential. Front Pharmacol 2022,13,943967 Evid Based Complement Alternat Med Song X. 2021 1 2021 10.1155/2021/5103626 Song X.; Yue Z.; Nie L.; Zhao P.; Zhu K.; Wang Q.; Biological functions of diallyl disulfide, a garlic-derived natural organic sulfur compound. Evid Based Complement Alternat Med 2021,2021,1-13 FASEB J Yang J. 33 7261 2019 10.1096/fj.201802172R Yang J.; Tang R.; Yi J.; Chen Y.; Li X.; Yu T.; Fei J.; Diallyl disulfide alleviates inflammatory osteolysis by suppressing osteoclastogenesis via NF-κB-NFATc1 signal pathway. FASEB J 2019,33(6),7261-7273 Anc Sci Life Mikaili P. 33 131 2013 10.4103/0257-7941.139059 Mikaili P.; Mojaverrostami S.; Moloudizargari M.; Aghajanshakeri S.; Pharmacological and therapeutic effects of Mentha Longifolia L. and its main constituent, menthol. Anc Sci Life 2013,33(2),131-138 J Geriatr Phys Ther Topp R. 36 92 2013 10.1519/JPT.0b013e318268dde1 Topp R.; Brosky J.A.; Pieschel D.; The effect of either topical menthol or a placebo on functioning and knee pain among patients with knee OA. J Geriatr Phys Ther 2013,36(2),92-99 Front Nutr Surendran S. 8 699666 2021 10.3389/fnut.2021.699666 Surendran S.; Qassadi F.; Surendran G.; Lilley D.; Heinrich M.; Myrcene-what are the potential health benefits of this flavouring and aroma agent? Front Nutr 2021,8,699666 Eur J Pharmacol Rufino A.T. 750 141 2015 10.1016/j.ejphar.2015.01.018 Rufino A.T.; Ribeiro M.; Sousa C.; Judas F.; Salgueiro L.; Cavaleiro C.; Mendes A.F.; Evaluation of the anti-inflammatory, anti-catabolic and pro-anabolic effects of E-caryophyllene, myrcene and limonene in a cell model of osteoarthritis. Eur J Pharmacol 2015,750,141-150 Front Pharmacol Zhou J. 13 1014105 2022 10.3389/fphar.2022.1014105 Zhou J.; Xie X.; Tang H.; Peng C.; Peng F.; The bioactivities of sclareol: A mini review. Front Pharmacol 2022,13,1014105 Int J Clin Exp Pathol Zhong Y. 8 2365 2015 Zhong Y.; Huang Y.; Santoso M.B.; Wu L.D.; Sclareol exerts anti-osteoarthritic activities in interleukin-1β-induced rabbit chondrocytes and a rabbit osteoarthritis model. Int J Clin Exp Pathol 2015,8(3),2365-2374 J Nat Prod Huang G.J. 75 54 2012 10.1021/np200512a Huang G.J.; Pan C.H.; Wu C.H.; Sclareol exhibits anti-inflammatory activity in both lipopolysaccharide-stimulated macrophages and the λ-carrageenan-induced paw edema model. J Nat Prod 2012,75(1),54-59 Pharmaceuticals (Basel) Pottoo F.H. 15 408 2022 10.3390/ph15040408 Pottoo F.H.; Ibrahim A.M.; Alammar A.; Alsinan R.; Aleid M.; Alshehhi A.; Alshehri M.; Mishra S.; Alhajri N.; Thymoquinone: review of its potential in the treatment of neurological diseases. Pharmaceuticals (Basel) 2022,15(4),408 Exp Biol Med (Maywood) Chen W.P. 235 1425 2010 10.1258/ebm.2010.010174 Chen W.P.; Tang J.L.; Bao J.P.; Wu L.D.; Thymoquinone inhibits matrix metalloproteinase expression in rabbit chondrocytes and cartilage in experimental osteoarthritis. Exp Biol Med (Maywood) 2010,235(12),1425-1431 Front Cell Dev Biol Kalamegam G. 8 646 2020 10.3389/fcell.2020.00646 Kalamegam G.; Alfakeeh S.M.; Bahmaid A.O.; AlHuwait E.A.; Gari M.A.; Abbas M.M.; Ahmed F.; Abu-Elmagd M.; Pushparaj P.N.; In vitro evaluation of the anti-inflammatory effects of thymoquinone in osteoarthritis and in silico analysis of inter-related pathways in age-related degenerative diseases. Front Cell Dev Biol 2020,8,646 Inflammation Wang D. 38 2235 2015 10.1007/s10753-015-0206-1 Wang D.; Qiao J.; Zhao X.; Chen T.; Guan D.; Thymoquinone inhibits IL-1β-induced inflammation in human osteoarthritis chondrocytes by suppressing NF-κB and MAPKs signaling pathway. Inflammation 2015,38(6),2235-2241 Molecules Kowalczyk A. 25 4125 2020 10.3390/molecules25184125 Kowalczyk A.; Przychodna M.; Sopata S.; Bodalska A.; Fecka I.; Thymol and thyme essential oil-new insights into selected therapeutic applications. Molecules 2020,25(18),4125 Inflamm Res Bouhtit F. 71 887 2022 10.1007/s00011-022-01573-3 Bouhtit F.; Najar M.; Rahmani S.; Melki R.; Najimi M.; Sadki K.; Boukhatem N.; Twizere J.C.; Meuleman N.; Lewalle P.; Lagneaux L.; Merimi M.; Bioscreening and pre-clinical evaluation of the impact of bioactive molecules from Ptychotis verticillata on the multilineage potential of mesenchymal stromal cells towards immune- and inflammation-mediated diseases. Inflamm Res 2022,71(7-8),887-898 Plants Ibáñez M.D. 12 5 2022 10.3390/plants12010005 Ibáñez M.D.; Sánchez-Ballester N.M.; Blázquez M.A.; Healthy Zerumbone: From natural sources to strategies to improve its bioavailability and oral administration. Plants 2022,12(1),5 Int J Mol Sci Chien T.Y. 17 249 2016 10.3390/ijms17020249 Chien T.Y.; Huang S.; Lee C.J.; Tsai P.W.; Wang C.C.; Antinociceptive and anti-inflammatory effects of zerumbone against mono-iodoacetate-induced arthritis. Int J Mol Sci 2016,17(2),249 Available from: https://www.nccih.nih.gov/health/glucosamine-and-chondroitin-for-osteoarthritis Available from: https://www.webmd.com/vitamins/ai/ingredientmono-1033/hesperidin Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Capsaicin Hylan polymers A and B (Injection route, intra-articular route) description and brand names - mayo clinic. Available from: https://www.mayoclinic.org/drugs-supplements/hylan-polymers-a-and-b-injection-route-intra-articular-route/description/drg-20074573 (Accessed on: 2023 May 28). Sodium hyaluronate injection uses, side effects and warning. Available from: https://www.drugs.com/mtm/sodium-hyaluronate-inject ion.html (Accessed on: 2023 May 28). Clin Cases Miner Bone Metab Migliore A. 12 31 2015 10.11138/ccmbm/2015.12.1.031 Migliore A.; Procopio S.; Effectiveness and utility of hyaluronic acid in osteoarthritis. Clin Cases Miner Bone Metab 2015,12(1),31-33

Item Type: Article
Subjects: Pharmacognosy > Phytochemistry
Divisions: Pharmacognosy
Depositing User: Mr IR Admin
Date Deposited: 08 Oct 2024 10:00
Last Modified: 08 Oct 2024 10:00
URI: https://ir.vistas.ac.in/id/eprint/9481

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