CHARACTERISATION OF PREPARED CEFIXIME AND METRONIDAZOLE WITH CHITOSAN NANOPARTICLE FOR PHARMACEUTICAL APPLICATION

Naturally existing polymer compounds, particularly polysaccharide polymers, have been employed in pharmaceuticals to deliver a wide range of therapeutic medicines. Next to cellulose-β-(1,4) linked N-acetyl-D-glucosamine units, chitosan is the second most prevalent naturally occurring polysaccharide. It is a mucoadhesive polymer that is biocompatible and biodegradable and has been widely used in the creation of both micro- and nanoparticles. Natural polymers made of randomly arranged N-acetyl- D-glucosamine (acetylated unit) and deacetyl-D-glucosamine (deacetylated unit) are chitin and its deacetylated derivative chitosan. Due to the free protonable amino groups found in the D-glucosamine units, chitosan is soluble in acidic environments whereas chitin is insoluble in aqueous media. Chitosan is a particularly promising
source for pharmaceutical application. Applications of chitosan as a wound dressing material include development of antimicrobial agents, chitosan bandage for wound healing, suitable for starting material for wound dressings, its hemostatic effect ability to inhibit microbial growth. Chitosan is biodegradable non-toxic natural polymer
that promotes wound healing and can be used as antibiotics for bacterial control by chitosan-based wound dressings. Due to its inherent antibacterial qualities and capacity to transfer extrinsic antimicrobial agents to wounds and burns, chitosan is used to treat wound and burn infections.