Preparation and evaluation of Pramipexole dihydrochloride loaded chitosan nanoparticles for brain-targeting

The present investigation was undertaken to develop nanoparticles of a hydrophilic drug pramipexole
dihydrochloride and improve the entrapment efficiency of the drug. Pramipexole dihydrochloride nanoparticles
where prepared with two methods by using Chitosan and another method by utilizing Chitosan, sodium alginate
and Pluronic F-127. Five different trials were prepared with different concentrations of Chitosan in both
methods. In two methods variables were found to have significant effect on the particle size, entrapment
efficiency of drug which is influenced by Chitosan and sodium alginate. The maximum entrapment efficiency
and least particle size were obtained with 3% Chitosan along with sodium alginate PS3 of 220.7 nm with 32.4
mV zeta potential with 91.2 % entrapment efficiency but in PC3 with 3% Chitosan show least particle size of
252nm with 44.7 mV zeta potential but less entrapment efficiency 82.8 % of than PS3.The surface morphology
of PC3 and PS3 shows smooth surface with the in vitro release of PC3 with 90.2 %, PS3 with 96.12% in 24 hrs.
PS3 shows better entrapment efficiency than PC3, Hence preparation methods along with two polymers may
influence in entrapment efficiency of pramipexole dihydrochloride nanoparticles which meet the treatment of
Parkinson’s disease which has a potential influence on brain-targeting