Clinical Assessment and Comparison of Lipid Profiles among Coronary Artery Disease and type 2 Diabetes Mellitus Patients receiving Statin Therapy

Aim and Objective: The aim of study is to assess and compare the lipid profiles among diabetic and coronary
artery disease (CAD) patients receiving statin therapy. Methods: This retrospective observational study was
carried out in a cardiac specialty hospital for a period of 6 months from January - June 2015. The inclusion
criteria included adult patients greater than 18 years of age with the diagnosis of coronary artery disease or
diabetes mellitus receiving statin therapy. CAD patients with any other co morbidity were excluded in the study.
Lipid profile such as low-density lipoproteins (LDL), high-density lipoproteins (HDL), very-low-density
lipoprotein (VLDL), total cholesterol (TC), triglycerides (TGL) were assessed. Results: The overall prevalence
of dyslipidemia in our CAD patients was greater. More number of male patients was affected with CAD and
diabetes when compared to female patients. No significant changes were observed in HDL levels. The study
concludes that the incidence and the lipid profile for both the study groups were found to be high. The lipid
parameters were assessed and compared for both the study groups which showed statistically no significance
difference. Aggressive therapy of diabetic dyslipidemia will probably reduce the risk of coronary heart diseases
(CHD) in patients with diabetes. Lowering triglycerides and increasing HDL cholesterol with a fibrate is
associated with a reduction in cardiovascular events in patients with clinical CHD, low HDL, and near-normal
levels of LDL.