Pharmacokinetics of Tacrine Loaded MPEG-PCL Polymeric Nanoparticles

The Tacrine loaded mPEG-PCL nanoparticles were prepared by emulsion polymerization and solvent
evaporation method, to improve the bioavailability of the drug in brain. The nanoparticulate formulation was
characterized for particles size, encapsulation efficiency, zeta potential and in vitro release study. The
pharmacokinetic studies of Tacrine-loaded mPEG-PCL nanoparticles were carried out in Sprague dawley rats.
The study revealed Cmax and Tmax were significantly altered and Clearance was less in brain and blood when
compared to that of plain Tacrine solution. These results suggest that mPEG-PCL nanoparticles had considerably
increased the transport of Tacrine across the BBB