Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines

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Rani, Chekuri Sharmila and Reddy, Alugubelli Gopi and Susithra, E. and Mak, Kit-Kay and Pichika, Mallikarjuna Rao and Reddymasu, Sreenivasulu and Rao, Mandava Venkata Basaveswara (2021) Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines. Medicinal Chemistry Research, 30 (1). pp. 74-83. ISSN 1054-2523

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Official URL: https://doi.org/10.1007/s00044-020-02638-w

Abstract

A novel series of amide functionalized imidazo[1,2-a]pyridine (14a–14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14j showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC50 values of 0.021 ± 0.0012 µM, 0.95 ± 0.039 µM, 0.091 ± 0.0053 µM, and 0.24 ± 0.032 µM, respectively

Item Type:	Article
Subjects:	Chemistry > organic Chemistry
Divisions:	Chemistry
Depositing User:	Mr IR Admin
Date Deposited:	09 Oct 2024 06:14
Last Modified:	09 Oct 2024 06:14
URI:	https://ir.vistas.ac.in/id/eprint/9213

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