A Complexity Focus on Nanotoxicology-A Review

This article will discuss some of the general considerations on the complexity of Nanotoxicology (NT). The real
scope of Nanotoxicology involves many processes. Nanotoxicology is an emerging discipline evolving from
studies of ultrafine particles called the nano-particles (NP). The small size facilitates uptake into cells and
transcytosis across epithelial and endothelial cells into the blood and lymph circulation to reach potentially
sensitive target sites such as bone marrow, lymph nodes, spleen, and heart. Access to the central nervous system
(CNS) and ganglia via translocation along axons and dendrites of neurons, evidences of mitochondrial
distribution and oxidative stress response after NSP endocytosis point to a need for basic research on their
interactions with subcellular structures.