Study on the adverse reactions of antipsychotics and therapeutic drug monitoring of olanzapine in psychiatric patients

Antipsychotics used in the treatment of psychotic disorders such as schizophrenia are generally associated with potential adverse effects. They mainly act by blocking dopaminergic uptake by binding to its receptors in the post synaptic nerve terminals. However their potential peripheral and extra pyramidal adverse effects have led to patient non-compliance of medications. Hence a clear understanding of the adverse effects associated with anti-psychotic therapy could ultimately yield better therapeutic outcomes and increase patient adherence to medications. The study was designed to analyse the common adverse reactions caused by antipsychotic medications. Olanzapine was found to be associated with greater risk of adverse effects and hence the plasma concentration of olanzapine was monitored.