Enhanced electrochemical sensing of dopamine in the presence of AA and UA using a curcumin functionalized gold nanoparticle modified electrode

Enhanced electrochemical sensing of dopamine in the presence of AA and UA using a curcumin functionalized gold nanoparticle modified electrode K. Krishna Kumar Department of Analytical Chemistry School of Chemical Science University of Madras Chennai India M. Devendiran Central Instrumentation Laboratory (CIL) Department of Chemistry School of Basic Science Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai R. A. Kalaivani Central Instrumentation Laboratory (CIL) Department of Chemistry School of Basic Science Vels Institute of Science, Technology and Advanced Studies (VISTAS) Chennai S. Sriman Narayanan Department of Analytical Chemistry School of Chemical Science University of Madras Chennai India http://orcid.org/0000-0003-0519-4011

In the present study, a electrochemical sensor for the determination of dopamine was developed with green synthesised gold nanoparticles using curcumin as a reducing and, functionalizing agent.
In the present study, a green synthesis of gold nanoparticles was carried out using curcumin as a reducing and functionalizing agent. We have developed a chemically modified electrode using curcumin functionalized gold nanoparticles (CR–GNP) which acted as a redox mediator for the electrochemical oxidation of dopamine in the presence of ascorbic acid and uric acid. Overall, CR–GNP was a stable electrode material and exhibited a synergistic effect towards enhanced electrochemical behavior, increased reaction kinetics, and selectivity in dopamine sensing. Surface characterization, surface composition analysis, physico-chemical property and electrochemical measurements were performed for the CR–GNP modified electrode. This electrode exhibited an enhanced electrochemical behavior towards sensing of dopamine by minimizing the oxidation potential from +0.23 V to +0.18 V and the CR–GNP modified electrode showed a higher oxidation peak current when compared with the bare and curcumin modified electrodes. Hydrodynamic measurements of dopamine were carried out using the chronoamperometry technique and static measurements were carried out using cyclic voltammetry and linear sweep voltammetry techniques. Under optimal conditions the modified electrode exhibited linearity in the calibration plot for dopamine concentrations ranging from 0.4 × 10 −6 to 5.6 × 10 −5 M. This work explored selectivity towards oxidation of dopamine in the presence ascorbic acid and uric acid with a detection limit of 4.2 × 10 −8 M.
2019 19003 19013 1 10.1039/rsc_crossmark_policy rsc.org true This document is Similarity Check deposited Supplementary Information S. Sriman Narayanan (ORCID) S. Sriman Narayanan (ResearcherID) Single-blind Received 25 August 2019; Accepted 31 October 2019; Accepted Manuscript published 1 November 2019; Advance Article published 20 November 2019; Version of Record published 9 December 2019 University of Madras http://dx.doi.org/10.13039/100010786 http://dx.doi.org/10.13039/100010786 http://rsc.li/journals-terms-of-use 10.1039/C9NJ04398E 20191209114336 https://xlink.rsc.org/?DOI=C9NJ04398E http://pubs.rsc.org/en/content/articlepdf/2019/NJ/C9NJ04398E Anal. Chim. Acta Sun 751 59 2012 10.1016/j.aca.2012.09.006 Trends Neurosci. Lévesque 30 1 22 2007 10.1016/j.tins.2006.11.006 Cell Zhou 83 1197 1995 10.1016/0092-8674(95)90145-0 J. Sep. Sci. Ye 37 2239 2014 10.1002/jssc.201400287 Electrochim. Acta Sun 87 317 2013 10.1016/j.electacta.2012.09.050 Analyst Guo 138 2683 2013 10.1039/c3an36669c Small She 10 22 4685 2014 10.1002/smll.201401471 TrAC, Trends Anal. Chem. Sajid 76 15 2016 10.1016/j.trac.2015.09.006 IOSR J. Environ. Sci., Toxicol. Food Technol. Paul 1 4 01 2015 Colloids Surf., B Priya 97 90 2012 10.1016/j.colsurfb.2012.04.004 Chem. Mater. Ahmad 27 16 5464 2015 10.1021/acs.chemmater.5b00138 Sens. Actuators, B Prabhu 156 606 2011 10.1016/j.snb.2011.02.006 Spectrochim. Acta, Part A Bindhu 128 37 2014 10.1016/j.saa.2014.02.119 Int. J. Nanomed. Elia 9 1 4007 2014 J. Mater. Chem. Lee 21 13316 2011 10.1039/c1jm11592h RSC Adv. Devendiran 6 32560 2016 10.1039/C6RA01756H Electrochim. Acta Yousef Elahi 54 490 2008 10.1016/j.electacta.2008.07.042 Anal. Methods Ouyang 6 18 7496 2014 10.1039/C4AY00884G Electroanalysis Ciszewski 7 12 1995 J. Solid State Electrochem. Zheng 14 43 2010 10.1007/s10008-008-0780-3 J. Solid State Electrochem. Yousef Elahi 11 273 2007 10.1007/s10008-006-0104-4 Electrochim. Acta Majdi 52 4622 2007 10.1016/j.electacta.2007.01.022 Int. J. Electrochem. Sci. Ragu 11 9133 2016 10.20964/2016.11.09 Electroanalysis Ciszewski 15 5–6 518 2003 10.1002/elan.200390062 Nanoscale Singh 5 1882 2013 10.1039/c2nr33776b Sens. Actuators, B Prabhu 156 606 2011 10.1016/j.snb.2011.02.006 Trends Anal. Chem. Scholz 11 359 1992 10.1016/0165-9936(92)80025-2 J. Am. Chem. Soc. Polte 132 1296 2010 10.1021/ja906506j Appl. Spectrosc. Canamares 60 1386 2006 10.1366/000370206779321337 Am. J. Chem. Rodrigues 2 3 157 2012 10.5923/j.chemistry.20120203.10 RSC Adv. Kesavan 6 62876 2016 10.1039/C6RA15821H Adv. Nat. Sci.: Nanosci. Nanotechnol. Nguyen 7 035003 2016 Anal. Chem. Nicholson 37 11 1351 1965 10.1021/ac60230a016 Analyst Mani 140 5764 2015 10.1039/C5AN00930H Electrochem. Commun. Nangia 14 51 2012 10.1016/j.elecom.2011.10.025 RSC Adv. Baek 4 21 10766 2014 10.1039/C4RA00256C Electroanalysis Raoof 17 22 2043 2005 10.1002/elan.200403332 RSC Adv. Qian 4 55473 2014 10.1039/C4RA08468C Electrochim. Acta Vasantha 52 665 2006 10.1016/j.electacta.2006.05.052 J. Electroanal. Chem. Dinesh 804 116 2017 10.1016/j.jelechem.2017.09.054 Sens. Actuators, B Jedrzak 256 176 2018 10.1016/j.snb.2017.10.079 Bioelectrochem. Bioenerg. Yang 48 117 1999 10.1016/S0302-4598(98)00222-0 Electroanalysis Goyal 20 7 757 2008 10.1002/elan.200704073 Electroanalysis Manjunatha 21 20 2198 2009 10.1002/elan.200904662