A comparative study of pregabalin and gabapentin combinations in type 2 diabetic neuropathy patients

Diabetes is a metabolic disorder; most of the patients are affected with nerve pain called neuropathic pain, which is acomplication that arises from diabetes called diabetic neuropathy. Diabetic Neuropathy Patients (DNP) results if the diabetic patient has high blood sugar levels for a long period. These high sugar level can damage the vessels that supplies blood to the nerve.
Aim and Objective: To evaluatethe effectiveness of drug in Diabetic Neuropathic Patients (DNP). Materials and Methods: The study was carried out at general medicine department as a prospective study for 6 months using data entry form and pain rating scale form. Results: In this study, 150patients with diabetic neuropathic pain were included and out of this 75 patients were given with Pregabalin + Alpha lipoic acid and remaining 75 were given with Gabapentin + Methylcobalamine therapy and the patients were selected based on the inclusion and exclusion criteria and the statistical analysis was done by Microsoft excel. Conclusion: From the present study we concluded that monotherapy with Pregabalin+Alphalipoic acid or Gabapentin+ Methylcobalamine produces clinically meaningful pain relief in patients with painful diabetic neuropathy and pain reduction was superior with Gabapentin+ Methylcobalamine compared to Pregabalin+Alphalipoic acid