Synthesis of novel three compound imidazole derivatives via Cu(II) catalysis and their larvicidal and antimicrobial activities

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Alaklab, Abdullah and Surendra Kumar, Radhakrishnan and Ahamed, Anis and Arif, Ibrahim A. and Manilal, Aseer and Idhayadhulla, Akbar (2017) Synthesis of novel three compound imidazole derivatives via Cu(II) catalysis and their larvicidal and antimicrobial activities. Monatshefte für Chemie - Chemical Monthly, 148 (2). pp. 275-290. ISSN 0026-9247

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Official URL: https://doi.org/10.1007/s00706-016-1746-2

Abstract

One-pot three-component reactions of 1-[[2-
(furan-2-ylmethylene)hydrazinyl](phenyl)methyl]-1H-imidazole and other imidazole derivatives were synthesized by
Mannich base method in the presence of Cu(II) catalysis.
Cu(Phen)Cl2 catalysis was performed well compared with
other Cu(II) catalysis. Synthesized compounds were confirmed by IR, 1
H NMR, 13C NMR, mass spectra, and
elemental analysis. Synthesized compounds were evaluated
by antimicrobial and larvicidal activities. 4-[[2-(Furan-2-
ylmethylene)hydrazinyl](1H-imidazol-1-yl)methyl]-N,Ndimethylaniline was highly active (MIC: 0.5 lg/cm3
)against Staphylococcus aureus compared with standard
ciprofloxacin in antibacterial screening. 1-[(4-Chlorophenyl)[2-(furan-2- ylmethylene)hydrazinyl]methyl]-1Himidazole was highly active (MIC: 0.25 lg/cm3
) against

Item Type:	Article
Subjects:	Biomedical Engineering > Biomedical Engineering Design
Divisions:	Biomedical Engineering
Depositing User:	Mr IR Admin
Date Deposited:	04 Oct 2024 07:04
Last Modified:	04 Oct 2024 07:04
URI:	https://ir.vistas.ac.in/id/eprint/8607

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