Fabrication of nanoparticles using Annona squamosa leaf and assessment of its effect on liver (Hep G2) cancer cell line

Abstract. Annona squamosa is a fruit bearing plant possesses potent bioactive compounds in
all its part. In this present investigation iron oxide nanoparticle was synthesized from
hydroethanol extract of Annona squamosa leaves at 600
c temperature. Production of iron
oxide nanoparticles in extraction is detected by UV–V spectrophotometer, Scanning electron
microscopy was employed to analyse the structure of nanoparticles. Fourier transform infrared
spectroscopy (FT-IR) analysis were performed, in order to determine the functional groups on Annona squamosa leaves extract. The synthesized Fe3O4 NPs shows potential cytotoxicity against liver carcinoma cell line (HepG2), and there is no toxicity on the normal liver cell line.
Our reports confirmed that the Annona squamosa leaf is a very good eco-friendly and nontoxic bioreductant for the synthesis of Iron oxide nanoparticle and opens up further opportunities for fabrication of drugs towards cancer therap