In Vivo studies of Ophthalmic Ocular Insert Containing Aciclovir

Aciclovir is an antiviral drug used to treat viral infections like herpes simplex virus. The aim of the present
research work was to develop ocular inserts of aciclovir and evaluate their drug release for both in vitro and in
vivo. The draw backs of other ophthalmic formulations (solutions, suspensions, ointment) like poor
bioavailability, patient non compliance, quick drug elimination was overcome by formulating the drug in ocusert
formulation.1,2 The ocuserts was prepared by solvent casting technique using hydrophilic and hydrophobic
polymers. Eight formulations was prepared with formulation code of F1, F2, F3, F4, F5, F6, F7, F8.The satisfied
drug release was achieved in F2 formulation. The selected formulation F2 was subjected to sterilization before
performing in vivo studies.3,46 healthy rabbits are used for in vivo study. Draize irritation studies are carried out
to check the compatibility of ocusert in the eyes. After 21 days of irritation study the eyes are examined. Drug
content of the ocuserts are calculated at predetermined time intervals and subtracted from the initial
value.5Thein