Impact of Nanoparticulate Drug Delivery System of Herbal Drug in Control of Diabetes Mellitus

Aim: The main objective of the current study is to organize and evaluate polymeric nanoparticles for the selected
drug Gymnemic acid, improve the bioavailability of poorly bioavailable gymnemic acid, enhance the antidiabetic activity of Gymnemic acid, reduce the dose size of Gymnemic acid by reducing the particle size.
Method and procedure: Gymnemic acid nanoparticles was prepared through emulsion-droplet coalescence
method, by using chitosan polymer (GNP1-GNP5). Based on the invitro drug release profile of Gymnemic acid
nanoparticles formulations (GNP1-GNP5) formulation GNP3 is selected as the best preparation in which the
particle size was 195 nm[1]. Since from ancient times the naturopathic treatment for diseases has been explored
widely and in advance momentum in the present situation, and has several pharmacological significance. Nano
particulate drug delivery systems symbolize a promising drug delivery system[2] in recent years for its prescribed
and targeted drug release. They exists as with a size choice of 10-1000nm, in which the drug or dissolved active
ingredient, encapsulated, entrapped, absorbed or attached to the matrix system. The present research is a
development of nanoparticulate[3,4] drug delivery system for Gymnema sylvestre by ionic gelation method. The
formulation is characterized by particle size, zeta potential, particle morphology and best formulation was
selected for the further studies. Result: The Gymnemic acid nanoparticles [1] were formulated and evaluated for
its invitro drug release profile. The results showed that the in vitro drug release for GNP1, GNP2, GNP3, GNP4
and GNP5 were found 99.55± 0.89, 99.51± 0.34, 99.57± 0.31,78.82± 0.82 and 65.73± 0.62 respectively at the
end of 24hrs. Conclusion: It can be concluded that the newly formulated controlled release nanoparticulate drug
delivery[32] systems of Gymnemic acid may be ideal and effective in the treatment of diabetes mellitus by
allowing the drug to release continuously for 24 hrs.