Formulation of PLGA Polymeric Nanosuspension containing Pramipexole Dihydrochloride for improved treatment of Parkinson's Diseases

Aim and Objectives The present investigation was undertaken to develop nanosuspension of a hydrophilic drug pramipexole dihydrochloride and improve the entrapment efficiency of the drug.Materials and Methods: Nanosuspension of pramipexole dihydrochloride was prepared with PLGA and Pluronic F68 by the process of modified nanoprecipitation technique. The particle size, zeta potential, SEM,TEM and invitro dug release where performed. The cell viability study were performed by using SH-SY5Y cells.