Formulation Development and Evaluation of Gastro Retentive Bio Adhesive Drug Delivery System for Moxifloxacin. HCl

Objective: The purpose of present research work is to develop gastro retentive formulation for Moxifloxacin using various drug release modifiers. Moxifloxacin, novel
synthetic fluoro quinolone, antibacterial agent. Methods: SR granules were prepared by gastro retentive tablets of Moxifloxacin. HCl were prepared using variable amounts of
HPMCK100M, Lannea coromandelica gum (LCG) by moist granulation technique. Totally10 SR granule formulations were prepared and subjected to precompression analysis and
drug release profiles. Based on the results screening of concentrations for polymers and are used for Tablet formulations. Six tablet formulations were designed and are evaluated for various pharmacopoeial tests. Drug release profiles of formulation trails subjected to kinetic modeling. a,b,r were determined. Results: The results reveals that retention time decreases with decreased viscosity of polymer. F16 prepared with LCG was found to
have highest swelling property. High bioadhesive strength of the formulation is likely to increase its GI residence time. Lannea coromandelica gum powder needs to explored as
a sustain release material at commercial scale.