Anti-inflammatory and antimicrobial activities of novel pyrazole analogues

Abstract A new sequence of pyrazole derivatives (1–6) was synthesized from condensation technique under utilizing ultrasound irradiation. Synthesized compounds were characterized from IR,
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H NMR, 13C NMR, Mass and elemental analysis. Synthesized compounds (1–6) were screened
for antimicrobial activity. Among the compounds 3 (MIC: 0.25 lg/mL) was exceedingly antibacterially active against gram negative bacteria of Escherichia coli and compound 4 (MIC: 0.25 lg/mL)
was highly active against gram positive bacteria of Streptococcus epidermidis compared with standard Ciprofloxacin. Compound 2 (MIC: 1 lg/mL) was highly antifungal active against Aspergillus
niger proportionate to Clotrimazole. Synthesized compounds (1–6) were screened for antiinflammatory activity and the compound 2-((5-hydroxy-3-methyl-1H-pyrazol-4-yl)(4-nitrophenyl)
methyl)hydrazinecarboxamide (4) was better activity against anti-inflammatory when compared
with standard drugs (Diclofenac sodium). Compounds (2, 3 and 4) are the most important molecules
and hence the need to develop new drugs of antibacterial, antifungal and anti-inflammatory agents.
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an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).