STUDIES ON HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITY OF COIX LACRYMA–JOBI (LINN)

STUDIES ON HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITY OF COIX LACRYMA–JOBI (LINN) Geetha S Jannathul Firdous Karpagam T Varalakshmi B Shanmuga Priya Sugunabai J Gomathi S

Objective: In the present study, evaluation of hepatoprotective activity of Coix lacryma-jobi by CCl4-induced hepatotoxicity test, and evaluation of anti-inflammatory activity of by egg albumin-induced paw edema, and complete Freund’s adjuvant-induced arthritis model were done.Methods: Plant extract was prepared by mixing ethanol with powdered plant seeds and experiment was done as per the procedures of above-mentioned three models.Results: C. lacryma-jobi test extracts out of two doses, 400 mg/kg exhibited a significant reduction in serum cholesterol level as 33 mg/dl when compared to control groups. C. lacryma-jobi seed extract has restored various serological alterations following CCl4-induced hepatotoxicity and was capable of reversing the toxic effects of CCl4 on liver cells. Considerable reduction in the paw volume of exudates observed with C. lacryma-jobi extract, indicating significant anti-inflammatory activity.Conclusion: Therefore, this study shows that C. lacryma-jobs seed extract have anti-inflammatory activity in the models studied.
11 07 2018 290 293 10.22159/ajpcr.2018.v11i11.26307 https://innovareacademics.in/journals/index.php/ajpcr/article/view/26307 https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/26307/16061 https://innovareacademics.in/journals/index.php/ajpcr/article/viewFile/26307/16061