Phytochemical Evaluation and In vitro Antidiabetic Activity of Ethanolic Extract of Amaranthus tristis Linn.

The digestive enzymes like alpha-glucosidase and alpha-amylase played a vital role in the carbohydrate metabolism. Alphaglucosidase inhibitors are the saccharides that act as hardies in the small intestine.Antidiabetic therapeuticapproach to reduce
the postprandial glucose level in blood by the inhibition of alpha-glycosidase and alpha-amylase enzymes. These can be a
major strategy for the management of blood glucose level in the body. The aim of the present study was to investigate the
phytochemical biomarker compounds of the ethanolic extract of Amaranthus tristis Linn leaves and its in-vitro antidiabetic activity. The result suggests that the presence of bioactive compounds could be responsible for the versatile medicinal properties of this plant including diabetes and the extract exhibit the dose-dependent action by increasing the inhibitory effect on the alpha-glucosidase enzyme and alpha-amylase enzyme. The ethanolic extract of Amaranthus tristis Linn leaves study exhibited potent hypoglycemic activity by in vitro studies.