Design, Synthesis and In Silico Molecular Docking Study of N-carbamoyl-6-oxo-1-phenyl-1, 6-dihydropyridine-3-carboxamide derivatives as Fibroblast growth factor 1 inhibitor

A novel series of N-carbamoyl-6-oxo-1-phenyl-1, 6-dihydropyridine-3-carboxamide derivatives (A1-A6) were
synthesized by various substitution and their structures were confirmed by spectral and elemental analyses. The
cytotoxic activity of the newly synthesized compounds was docked against fibroblast growth factor 1 (FGF1).
These FGFR cascades play crucial roles in tumor cell proliferation, angiogenesis, migration, and survival.
FGFRs were also identified in a variety of human cancers such as ovarian cancer, myeloproliferative syndromes,
lymphomas, prostate and breast cancers as well as other malignant diseases. The molecular docking study was
used for confirming their interaction with fibroblast growth factor 1. Thorough in silico molecular docking study,
the result showed that all synthesized derivatives (A1-A6) have low binding energy (Table 1) and have good
affinity toward their active pocket. Thus the synthesized derivatives considered as good anti cancer agent