Comparative Study of efficacy of Ilaprazole and Omeprazole in Patients with Acid Peptic Disease

The aim of the study was to compare and evaluate whether there is any difference in efficacy between ilaprazole
and omeprazole in patients with acid peptic disease with symptoms.
Methods and materials:
A prospective randomized open label comparison was conducted in 100 patients in which 50 patients of group-A
received ilaprazole and 50 patients of group-B received omeprazole who visited the in-patients of general
medicine department over a period of 6 months.
Results:
Among 100 patients, the highest numbers of patients were from the age group of 18-30 years. Most commonly
diagnosed conditions were peptic ulcer, duodenal ulcer, gastro-esophageal reflux disease and gastritis. The
efficacy analyses were based on 100 patients. At week 4, 54% of male patients and 46% of female patients of
group-A treated with 5 mg ilaprazole, 10 mg ilaprazole and 46% of male patients and 54% of female patients of
group-B treated with 20 mg omeprazole once daily respectively had reduced heart burn, acid reflux symptoms
and ulcers healed. The majority of patients (>80%) became asymptomatic after 4 weeks treatment in group-A
compared with patients in group-B. Conclusion:
The present study showed that ilaprazole is more effective than omeprazole and low dose of ilaprazole offers a
gastric acid inhibition when compared to routine dose of omeprazole.