A review on the role of presenilin in alzheimer's disease

Alzheimer’s disease (AD) is the most common form of dementia. It characterized by the presence of numerous
senile plaques and neurofibrillary tangles in the cerebral cortex and hippocampus of affected individuals.
Mutations in the genes encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein
have been identified as the main genetic causes of familial AD. To date, more than 200 mutations have been described worldwide in PSEN1, which is highly homologous with PSEN2, while mutations in PSEN2 have been rarely reported.We performed a review of studies describing the mutations identified in PSEN1 and PSEN2. This article brings about the information pertaining to the role of presenilin and its derivatives in Alzheimer’s disease.