Methods of induction of Alzheimer's disease in rat and mice

Alzheimer's disease is known to be progressive dysfunction of neurons, which could be categorized under hereditary and sporadic conditions. The common cause of 70% of dementia, progression initiates slowly and thus worsens over a gradual increase of time. Noticed at an older age, especially geriatric level, which is difficult to attain relevant results in treatment. The cause of AD is undisclosed. The trademark of Alzheimer's disease is found to be deposition of peptides of β-amyloid, resembling a plague appearance in the central nervous system. The plague formed is expected to increase in size at the later stage. Initially, the disease is encountered with loss of memory, inability to recollect the recent issues practiced by the patient, especially of episodic memory. Different methods had been carried for induction of AD in mice through animal modeling technique, subsequent treatment to solubilize the plague is attained. The underlying mechanism of the disease progression could be explained through genetically modified animals which would support to attain therapeutic interventions and preclinical drug development. Combined deposition of Cu and Zn in Aβ is enriched and thus solubilized by Cu/Zn chelators in vitro, which would serve as a novel therapy for the prevention and treatment of AD. A comprehensive literature search has been carried out in PubMed and Google Scholar, and articles pertaining to complications of intravenous drug use were selected for review. [ABSTRACT FROM AUTHOR] Copyright of Drug Invention Today is the property of Journal of Pharmacy Research and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)