PREPARATION, CHARACTERISATION BY SPECTRAL ANALYSIS, BIOLOGICAL ACTIVITY AND DOCKING STUDIES OF AROMATIC 2,2′-DIFLUORO BENZILIC ACID

2,2′-difluoro benzilic acid is prepared by benzoin-benzilic acid rearrangement method.
The starting material benzoin was prepared by the reaction with simple benzaldehyde followed by the oxidation to get benzil. The target compound was synthesised and then purified. The compounds were characterised using IR, UV and NMR spectral studies which are used to determine the presence of functional groups and types of transitions. In vitro antibacterial activity was studied and docking studies were also carried out. Biochemical investigations revealed significant biological activity compared to those of respective controls.