Deciphering the Effect of Hydro-alcoholic extract of Cymodocea serrulata on the Cell Cycle Arrest and Apoptosis

Liver cancer is the most common cancer both in men and women. Hepato carcinoma is caused due to chemicals, food and also by even some drugs. Many therapies and therapeutic agents show side effects of liver cancer. A natural medicine Cymodoceae serrulata, seagrass under Cymodoceaceae family,
found in the subtidal region may prove a source of beneϐit to avoid such side effects. Hydro ethanol extract of Cymodoceae serrulata shows high antioxidant and pharmacological activities, which may be used for the treatment of liver cancer. The earlier stage of Apoptosis can be identiϐied by the nuclear changes such as DNA fragmentation. Propidium iodide can determine the proportion of cell cycle analysis—Annexin V conjugated to ϐluorochromes, including FITC. When the HepG2 test sample treated with the drug Cymodoceae serrulata, viable cell growth is signiϐicantly reduced compared to the standard
camptothecin, which is an antitumor agent. Percentage of viable cell count declined signiϐicantly to 5.38%, and the percentage of the late apoptotic cell increased impressively 42.08%.