Determining the Influence of Breadfruit Mucilage on the Disintegration and Dissolution of Losartan Fast-Dissolving Tablets

This study investigated breadfruit starch as a potential excipient for immediate-release losartan tablets. The solubility, pH,
organoleptic characteristics, hydration, swelling capacity, and pasting temperature of breadfruit starch were determined. It
was found that breadfruit starch exhibited partial solubility in warm water, a pH of 5.8, and good hydration and swelling
capacities. Furthermore, a compatibility test using differential scanning calorimetry confirmed the compatibility of losartan
and breadfruit starch. It was determined that the formulated losartan tablets were satisfactory in terms of flow properties as
well as consistent drug content both before and after compression. Dissolution studies in-vitro showed improved drug release
profiles than those of losartan tablets marketed on the market. According to stability studies, the physical appearance and color of the drug did not change over 3 months, but there was a slight decrease in the amount of the drug and the rate of drug release during that period. Overall, breadfruit starch showed promise as an excipient for losartan tablets, offering potential benefits in terms of enhanced drug release characteristics. Further investigations are necessary to optimize the formulation
and evaluate its clinical efficacy and safety.