Povidone-Iodine bonded with Natural Herb of Azadirachta indica (Neem) to increase the Antimicrobial Activity

Povidone iodine has long been used by surgeons as a preoperative antiseptic, researchers have been looking at
the agent for treating viral conjunctivitis as well as other ocular diseases. The antimicrobial skin-preparation
formula includes povidone-iodine and extract of Azadirachta indica (neem). The microbicidal action spectrum of povidone iodine (PI) is broad, even after short exposure times. Further, unlike local antibiotics and other antiseptic substances, no resistance seems to develop. The high degree of bactericidal efficiency with respect to highly resistant gram-positive pathogenic micro-organisms, such as methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus strains, has made the agent particularly useful and significant for hospital hygiene. The antibacterial activity of Azadirachta indica (neem) performed by using agar well diffusion method showed a result showcasing an effective limit when as opposed pseudomonas vulgaris for ethanol being used as solvent for extract. In Azadirachta indica (neem) leaves extract terminate most propitious source. Iodine and its antibacterial properties have been used for the prevention or management of wound infections for over 150 years. However, the use of solutions (tincture) of iodine has been replaced by the widespread use of ovidone- iodine, a water-soluble compound, which is a combination of molecular iodine and polyvinyl pyrrolidone. The resultant broad spectrum of antimicrobial activity is well documented and its efficacy, particularly in relation to resistant micro-organisms.