In silico approach to inhibit Synthetic HIV-TAT activity using Phytoconstituents of Moringa oleifera leaves extract

TAT (Trans-activator-Transcription Protein), a viral protein is encoded by the TAT gene in HIV-1-which is a
lethal subtype of HIV (Human immunodeficiency Virus). It is vital for the transcription of the viral genome.
Previous studies show that in Human TAT is a toxin-producing protein allowing cell death in normal T-cells.Thereafter allows for progression towards AIDS (Acquired munodeficiency syndrome). Traditionally herbalmedicines have played a vital role in the treatment of many diseases and ailments. lthough studies have beenconducted to find anti-HIV activities against other HIV-1 proteins, there are no traces of studies against HIVTrans-activator-Transcription protein (PDB: 1JFW). The main objective of this study is to find an efficaciousinhibitor against a synthetic HIV-TAT protein (PDB: IJFW). After a thorough literature survey, the molecular