PRSS-1 gene mutations in etiopathogenesis of pancreatic cancer

The genetic which alters the PRSS-1 (protease serine-1) gene results in chronic pancreatitis, which further causes
pancreatic cancer. The equilibrium of the protease and anti-protease is altered by the RI22H (A sub-mutation of
PRSS-1) which promote the onset of pancreatic cancer. Gene conversion is the major phenomenon which create
the nucleotide changes that affect the axon part of thePRSS-1 gene. Genetic factors, Alcoholism, smoking, lack
of the anti-oxidants were some of the factors, which causes the PRSS-1 gene mutations.