mPEG-PCL Nanoparticles as New Carriers for Delivery of a Prostae Cancer Drug Fluamide

mPEG-PCL Nanoparticles as New Carriers for Delivery of a Prostae Cancer Drug Fluamide S. Venkateswara Rao Department of Pharmaceutics, Vel’s Institute of Science, Technology and Advanced Studies (VISTAS), Vel’s University, Chennai–600117, Tamilnadu, India. S. Sathesh Kumar School of Pharmaceutical Sciences, Vel’s Institute of Science, Technology and Advanced Studies (VISTAS), Vel’s University, Chennai–600117, Tamilnadu, India.
The present work was aimed to prepare and evaluate Flutamide loaded methoxy poly (ethylene glycol) poly caprolactone (mPEG–PCL) nanoparticles for targeted delivery to the prostate cancer. The nanoparticles (NPs) were prepared by 23 factorial design and nanoprecipitation method. Various trials were evaluated for surface morphology, particle size and zeta potential. The influences of three formulation excipients such as polymer, stabilizer and organic phase volume on the characterization of NPs were investigated. The results of fourier transform infrared (FTIR) studies were indicated no interaction between the drug and polymer. The particle size varied from 79.2 to 89.1 nm and zeta potential value was found to be - 41.5 mv. The surface morphology of NPs was observed using scanning electron microscopy (SEM) and understands the arrangement and orientation of NPs to determine its behavior and stability. Flutamide loaded mPEG–PCL nanoparticle is a potential new carrier system for treatment of prostate cancer, which may overcome the problems associated with conventional formulations such as tablets. 7 19 2021 7 19 2021 3657 3661 10.52711/0974-360X.2021.00632 https://rjptonline.org/AbstractView.aspx?PID=2021-14-7-29 10.1016/j.biomaterials.2006.03.049 Mondrinos M. J, Dembzynski R., Byrapogu V. K, Wootton D. M, Lelkes P and Zhou J. Porogen based solid freeform fabrication of polycaprolactone calcium phosphate scaffolds for tissue engineering. Biomaterials. 2006; 27: 4399–4408. 10.1016/j.ejps.2004.07.011 Kim J and Bae Y. Albumin loaded microsphere of amphiphilic poly(ethylene glycol)/ poly(α-ester) multiblock copolymer. Eur J of Pharm Sci. 2004; 23: 245–251. 10.1080/2331205x.2016.1142411 Hossein Danafar. MPEG–PCL copolymeric nanoparticles in drug delivery systems. Cogent Medicine. 2016; 3: 1 – 11 10.1002/jbm.a.30008 Huang M. H, Hutmacher D. W, Schantz J. T, Vacanti C. A, Braud C and Vert M. Degradation and cell culture studies on block copolymers prepared by ring opening polymerization of p-caprolactone in the presence of poly(ethylene glycol). J Biomed Mater Res. 2004; 69: 417–427. Danafar H, Rostamizadeh K, Davaran S, Valizadeh H and Hamidi, M. Biodegradable m- PEG/PCL core- Shell Micelles: Preparation and characterization as a sustained release formulation for curcumin. Adv Pharm Bull. 2014; 4: 501–510. 10.1016/j.jconrel.2005.09.039 Park E. K, Kim S. Y, Lee S. B and Lee Y. M. Folate conjugated methoxy poly(ethylene glycol)/poly(ɛcaprolactone) amphiphilic block copolymeric micelles for tumor-targeted drug delivery. J Control Release. 2005; 109: 158–168. Chemical Structure of mPEG-PCL. https://www.google.com/ search?q =Chemical+Structure+of+mPEG-PCL B. V. Nagarjuna yadav, V. Ravichandiran, S. Sathesh kumar. Preparation and characterization of gemcitabine loaded mpeg-pcl polymeric nanoparticles for improved transportation across blood brain barrier. IJPPS. 2016; 8: 82 – 90 10.22159/ajpcr.2018.v11s4.31739 Venkateswara Rao S, Sathesh Kumar S. Design and Evaluation of Flutamide-Loaded Polycaprolactone Nanoparticles by 23 Factorial Design and Nanoprecipitation Method. Asian J Pharm Clin Res. 2018; 11: 203-210 10.3109/02652048.2014.995731 Dipsingh SN. Preparation and in vitro–in vivo evaluation of surface-modified poly(lactide-coglycolide) nanoparticles as controlled release carriers for flutamide delivery. J Microencapsul. 2015; 32: 231 – 239 10.2174/1567201813666161018152113 R. S. Surenya, Snima, K. S., V Shantikumar, N., and Lakshmanan, V. Kumar. Assessment of Poly (vinyl alcohol) Coated Flutamide Nanoparticulates and Their Efficacy on Prostate Cancer Cells. Curr Drug Deliv. 2016; 2: 312 - 339 10.2147/ijn.s40674 Ahmed O Elzoghby, Maged W Helmy, Wael M Samy and Nazik A Elgindy. Novel ionically crosslinked casein nanoparticles for flutamide delivery: formulation, characterization and in vivo pharmacokinetics. Int J Nanomedicine. 2013; 8: 1721–1732 10.1016/s0305-7372(02)00090-7 Martel CL, Gumerlock PH, Meyers FJ and Lara PN. Current strategies in the management of hormone refractory prostate cancer. Cancer Treat Rev. 2003; 29: 171–187. 10.1063/1.4858419 K. T. Arulmozhi and N. Mythili. Studies on the chemical synthesis and characterization of lead oxide nanoparticles with different organic capping agents. AIP Advances. 2013; 3: 122122 – 122129 10.1016/j.ejps.2004.04.003 Cegnar, M., Kos, J., Kristl, J. (2004) Cystatin incorporated in poly (lactide-co-glycolide) nanoparticles: development and fundamental studies on preservation of its activity. Eur J Pharm Sci. 22, pp. 357-364.