Biosynthesis and aquatic toxicity studies of gold nanoparticle in Catla catla

The gold nanoparticles generally find many applications in the drug delivery system, fluorescence biolabeling of tumor cells, bio detection of pathogens, probing of DNA structure and tissue engineering. Basically, the AuNPs are non- toxic in nature but it may induce DNA damage and increase the nuclear abnormalities levels. The AuNPs plays an important role in causing fish toxicity when the cells take up the particles and store them. The present study extensively investigated to analyse the in-vivo acute toxicity of gold nanoparticles in Catla cattle. The hematological studies and antioxidative responses were considered in the tissues of Catla cattle such as gills and liver. The results of this study exhibited the bioaccumulation of AuNPs in the tissue has caused due to the increasing doses of the nanoparticle. The hematological analysis showed considerable alterations in the gold nanoparticles treated fish. The impact of histological changes induced by gold nanoparticles were confirmed by the damages in the tissues, blood vessels, primary lamella and formation of vacuolation in gills and liver when compared with the control Catla cattle.