Activities of Thiazolidine-4-one and Azetidine-2-one Derivatives- A Review

Activities of Thiazolidine-4-one and Azetidine-2-one Derivatives- A Review Ramachandran S. Department of Pharmaceutical Analysis, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai - 600117, India. Binoy Varghese Cheriyan Department of Pharmaceutical Analysis, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai - 600117, India. M. Vijey Aanandhi Department of Pharmaceutical Analysis, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai - 600117, India.
Thiazolidine-4-ones containing thiazole moiety have been synthesized by condensing 6-amino Coumarin, Isatin and Primary amines, and aromatic aldehydes. Azetidine derivates were synthesized followed by cyclizations by C-N bond formation and by the C-C bond formation, the amine-catalyzed cycloaddition of allenoates and imines, photocycloadditions of imines and alkenes, ring contraction and expansion rearrangements, and reduction of azetidine-2-ones (β-lactams). Thiazolidine-4-ones has been considered as a magic moiety because it posses almost all types of biological activities such as Antifungal, Antitubercular, Antimicrobial, Antioxidant, Antibacterial, Cytotoxic, Anti-inflammatory, Analgesic, Anti YFV (yellow fever virus) activities. Azetidine-2-one derivatives were reported to possess antibacterial, antifungal and antidepressant activity, anticonvulsant activity, anti-inflammatory activity and cardiovascular activities, antimycobacterial activity, antihypertensive activity. This article is a review of various biological activities of thiazolidine-4-ones and Azetidine-2-ones derivatives.
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