Formulation and evaluation of capsule of ethanolic extract of Cnidoscolus chayamansa Mc Vaugh leaves for the treatment of diabetes

The present study aims in formulating and evaluating the herbal capsules containing the dried ethanol extract of Cnidoscolus chayamansa Mc Vaugh. The hot continuous percolation method of powdered plant materials was used in the extraction process using 70% v/v ethanol in the Soxhlet apparatus. The pre-formulation observations (Bulkdensity, Hausnser’sratio, Angleof recline, Tapped density and
Compressibility index) of C. chayamansa dried ethanolic extract was calculated, followed by the granules
formulation necessary for the encapsulation. Three different batches (F1 to F3) of dried ethanolic extract capsules were formulated and moisture content, drug content, disintegration, weight uniformity and dissolution of apsules produced were accomplished. The flow properties of the dried ethanolic extract and its formulated granules were found to be good. Among 3 formulations (F1 to F3), the F3 formulation
produced the optimal in vitro release (92.75% after 60 min) and uniformity of weight, drug content and disintegration test results were within the Pharmacopoeial standard. The ethanolic extract capsule of C. chayamansa leaves were well developed and found to be an utmost common dosage form utilized in the
successful control and maintenance of the metabolic condition, diabetes mellitus.