Controlled drug release for inflammatory bowel disease (IBD)

Controlled drug release in formulation is an important area of research. Formulations usingcrospovidone as super-disintegrants to achieve immediate release once it reaches the ileo- cecalregion is relevant. The Eudragit L30D pH dependent polymer that allows drug release after a lagtime of 4-5 hrs to achieve desired drug release from the drug delivery system is critical. Hence,pre-formulation to study drug-polymer interaction is essential. The linear correlation between thepredicted and actual values for all the batches of optimization is shown with high correlation coef‐ ficient (r-value). Therefore, the designed formulation is promising for ileo-cecal targeted pulsatiledrug delivery system in the management of Crohn's disease.