Disposable cerium oxide/graphene nanosheets based sensor for monitoring acebutolol in environmental samples and bio-fluids

The production and utilization of medicines strives to be an essential factor in the modern world in treatment,diagnosis and prevention. On the other hand, the medical discharge and the unmetabolized drugs all turns out intoenvironmental polluting agents. The demand for detecting and solving these issues are essential. Herein, we report anelectrochemical sensor for quantifying β-adrenoreceptor blocker acebutolol (ACT) in environmental and biologicalsamples. Cerium oxide
(CeO ) was implied with graphene nanosheets (GNS) as highly conducting material forelectrochemically detecting ACT. The structural and morphological studies were studied and electrochemical analysiswere also performed to efficiently study oxidation mechanism of ACT at CeO /GNS interface. Electrochemicalimpedance spectroscopy (EIS) proved the higher conducting behavior of CeO/GNS. Moreover, CeO
/GNS/SPCE holdshigher surface area with more edge sites facilitating the electro-oxidation of ACT. The linear range of detecting ACT wasin the range of 0.039 μM to 486.6 μM. The limit of detection was found to be 0.007 μM with the sensitivity about27.3 μAμ cm . The real samples like river water and urine samples were utilized for real time detection of ACT. Thus,the fabricated electrode with more efficiency and higher conducting property will enhance the real time sensing ofACT in environmental and biological samples.