SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL EVALUATIONS OF ACETYLOXYPHENYL-1,2,3- TRIAZOLOTETRAMETHYL HEXAHYDROACRIDINEDIONES

SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL EVALUATIONS OF ACETYLOXYPHENYL-1,2,3- TRIAZOLOTETRAMETHYL HEXAHYDROACRIDINEDIONES P. Shanmugasundaram R. Sujatha M. Vijey Aanandhi K. Saravanan P. Subbramaniyan

Tetramethyl-10-(2-hydroxyphenyl)-hexahydro acridinediones were treated with chloroacetyl chloride to give 10-(2- chloroacetyloxyphenyl)hexahydro acridinediones, which were treated with NaN3 in acetone followed by reaction with DMAD yielded tetramethyl-10-[2-(1-triazolo-4,5 dicarboxymethyl)acetyloxyphenyl]-3,4,6,7,9,10-hexahydro1,8-(2H,5H)-acridinediones. All the derivatives were screened for antimicrobial activity.
2022 2022 946 953 10.31788/RJC.2022.1526718 http://rasayanjournal.co.in/admin/php/upload/3559_pdf.pdf http://rasayanjournal.co.in/admin/php/upload/3559_pdf.pdf