In vitro anticancer activity of silver nanoparticles phyto-fabricated by Hylocereus undatus peel extracts on human liver carcinoma (HepG2) cell lines

Every year, millions of people die from cancer, and most
anticancer medications have a low specificity of action andsignificant toxicity, resulting in severe side effects. As a result, the discovery of effective anticancer
drugs is a toppriority. Hence, the focal point of this research is to synthesize the dragon fruit peel aqueous extract fabricated silvernanoparticles (DFPAE-AgNPs) in a facile and green chemistry approach as a new-fangled anticancer agent. The selectedprimary phytochemicals
are qualitatively screened for their presence in
dragon fruit peel aqueous extract utilized forthe fabrication of AgNPs. The analytical results revealed that DFPAE-AgNPs were crystalline, spherical in shape in thesize range of 10–50 nm, and composed of 73.90% weight of a silver element. The IC value of the DFPAE-AgNPs isevaluated as 37.98 ± 0.21 μg mL with a HepG2 cell line. Acridine orange-
ethidium bromide (AO-EtBr) staining andnuclear acid staining assays demonstrated the dose-dependent (10–50 μg mL) apoptotic increase phenomenon of theDFPAE-AgNPs in the HepG2 cell line at 24 h. The current study suggested DFPAE as a vital, reliable, and activephytoconstituents for the fabrication of AgNPs with anticancer potentials in a rapid and eco-friendly way. Furthermeticulous investigation on the DFPAE-AgNPs behavioral nature is recommended to make use of these as alternativesto synthetic drugs in wider anticancer applications.