Green synthesis of curcumin-silver nanoparticle and its modified electrode assisted amperometric sensor for the determination of paracetamol

Contamination of paracetamol, a primary analgesic was wide spread in the water system that affects the eco-system.High-dosage of paracetamol to humans cause organ damages and showed adverse effect. It is important to monitor theparacetamol concentration in environmental and human samples periodically. Conventional methods associated withchromatography is found to be high-cost, time consuming and requires high-end instrumentation, Herein, weinvestigated the role of curcumin during bio-synthesis of silver nanoparticles . The curcumin functionalized silver
nanoparticles were further chemically modifying on the electrode surface and the resulting modified electrode wasapplied for electrocatalytic oxidation of paracetamol. The experimental finding proved that the modified electrode iscapable of sensing paracetamol by applying oxidation potential 0.4 V. Both the synthesised material and modifiedelectrode surface were characterized for its physic-chemical properties using spectroscopy and microscopy techniques.The HR-TEM, FESEM and AFM results showed that the distribution of nanoparticle with the size range from 25 to 70 nmand the UV–Vis and Raman spectrophotometer characterization confirms the coordination between SNP and curcumin.Under optimized condition, in 0.1 M NH
Cl (pH 7) at the scan rate of 50 mVs . The modified electrode enhanced thesensitivity towards the detection of paracetamol in trace level. The modified electrode is capable of sensingparacetamol in a linear range between 0.59 × 10 and 342.1 × 10 M, with LOD of 0.29 μM, and linear regressionequation of y = 0.092x+502.6 with a correlation coefficient of R = 0.996.