Current Review on Polymeric Hydrogel Based: Pharmaceutical Sciences-Pharmaceutical analysis for Novel drug formulation

: Skin tissue defects have become one of the major sources of mortality and morbidity among all age group people
worldwide. Skin tissue engineering has enticed considerable heedfulness from researchers as an optimistic approach for repairing
partial/ full thickness burn tissue. Skin is a highly vascularized, bio mineralized composite material composed of fibroblasts and
collagen surrounded by specialized extracellular matrix with high mechanical strength and structural complexity. Although the
auto grafts and allografts were regarded as the high attainment for wound repair, the approach was limited due to their inability
revascularize and mimicking the damaged tissue. Further, the Polymeric hydrogels are very attractive skin tissue engineering
scaffolds. The structural similarity of the polymeric hydrogels to the skin extracellular matrix provides additional benefits for
non-invasive tissue repair. Owing to their poor healing ability, tissue regeneration was found to be challenging in skin tissue
defects. However due to its excellent moisture retaining capabilities, biocompatibility and biodegradability several researchers
shown considerable interest in potential applications of the hydrogels for skin tissue repair.Furthermore, recent progress
involves the development of hydrogels with ideal mechanical and fast stimulus responsive characteristics. Moreover, hydrogelswith structural similarity to the skin extracellular matrix up regulate the cell material interactions for quicker skin tissue repairand more regulated stimulus response changes in the microenvironment. This current review focused on the applications ofboth the synthetic and natural polymers involved in the formulation of the hydrogels for the skin tissue generation.Furthermore, understanding the polymers simultaneously reducing the