Research Progress of Indole Alkaloids: Targeting MAP Kinase Signaling Pathways in Cancer Treatment

Cancer is the leading cause of morbidity and mortality in people throughout the world.
There are many signaling pathways associated with cancerous diseases, from which the Mitogenactivated protein kinase (MAPK) pathway performs a significant role in this regard. Apoptosis
and proliferation are correlated with MAPK signaling pathways. Plenty of experimental investigations were carried out to assess the role of indole alkaloids in MAPK-mediated cancerous diseases.
Previous reports established that indole alkaloids, such as vincristine and evodiamine are useful
small molecules in cancer treatment via the MAPK signaling system. Indole alkaloids have the
anticancer potential through different pathways. Vincristine and evodiamine are naturally occurring indole alkaloids that have strong anticancer properties. Additionally, much research is ongoing or completed with molecules belonging to this group. The current review aims to evaluate how indole
alkaloids affect the MAPK signaling pathway in cancer treatment. Additionally, we focused on the advancement in the role of indole alkaloids, with the intention of modifying the MAPK signaling