ABSTRACT Amaranthus tricolor L. (Amaranthaceae), commonly known as edible amaranth or Chinese spinach, is a nutrient-dense leafy vegetable with significant ethnomedicinal importance. The present study aimed to evaluate the phytochemical composition and pharmacological activities of the hydroalcoholic extract of A. tricolor stem and roots. Preliminary phytochemical screening revealed the presence of key bioactive constituents, including alkaloids, carbohydrates, glycosides, saponins, proteins, amino acids, polyphenols, and terpenoids. Quantitative analysis indicated a considerable total phenolic content (1.5146 µg/g), suggesting strong antioxidant potential. The in vitro anti-diabetic activity demonstrated effective α-amylase inhibition with an IC₅₀ value of 115.98 µg/mL, comparable to the standard drug acarbose (125.81 µg/mL). Anti-inflammatory activity assessed by the human red blood cell (HRBC) membrane stabilization method showed dose-dependent inhibition, with an IC₅₀ value of 177.42 µg/mL, compared to diclofenac (114.03 µg/mL). Antioxidant activity evaluated using the DPPH radical scavenging assay exhibited significant free radical inhibition with an IC₅₀ value of 47.77 µg/mL. The extract demonstrated appreciable iron content, indicating its potential role in managing iron deficiency anemia. The observed pharmacological activities may be attributed to the presence of phenolic compounds and other phytoconstituents. The findings suggest that A. tricolor stem and root extracts possess promising anti-diabetic, anti-inflammatory, and antioxidant properties, along with nutritional benefits. Further in vivo and clinical studies are required to validate these results and elucidate the underlying mechanisms of action. Keywords: Amaranthus tricolor L.; Phytochemicals; Anti-diabetic activity; Anti-inflammatory activity and Antioxidant activity.

Amudha, P and Anadhabhairavi, N and Prakash, Vairakannu ABSTRACT Amaranthus tricolor L. (Amaranthaceae), commonly known as edible amaranth or Chinese spinach, is a nutrient-dense leafy vegetable with significant ethnomedicinal importance. The present study aimed to evaluate the phytochemical composition and pharmacological activities of the hydroalcoholic extract of A. tricolor stem and roots. Preliminary phytochemical screening revealed the presence of key bioactive constituents, including alkaloids, carbohydrates, glycosides, saponins, proteins, amino acids, polyphenols, and terpenoids. Quantitative analysis indicated a considerable total phenolic content (1.5146 µg/g), suggesting strong antioxidant potential. The in vitro anti-diabetic activity demonstrated effective α-amylase inhibition with an IC₅₀ value of 115.98 µg/mL, comparable to the standard drug acarbose (125.81 µg/mL). Anti-inflammatory activity assessed by the human red blood cell (HRBC) membrane stabilization method showed dose-dependent inhibition, with an IC₅₀ value of 177.42 µg/mL, compared to diclofenac (114.03 µg/mL). Antioxidant activity evaluated using the DPPH radical scavenging assay exhibited significant free radical inhibition with an IC₅₀ value of 47.77 µg/mL. The extract demonstrated appreciable iron content, indicating its potential role in managing iron deficiency anemia. The observed pharmacological activities may be attributed to the presence of phenolic compounds and other phytoconstituents. The findings suggest that A. tricolor stem and root extracts possess promising anti-diabetic, anti-inflammatory, and antioxidant properties, along with nutritional benefits. Further in vivo and clinical studies are required to validate these results and elucidate the underlying mechanisms of action. Keywords: Amaranthus tricolor L.; Phytochemicals; Anti-diabetic activity; Anti-inflammatory activity and Antioxidant activity. The International Journal of Drug Delivery Technology (IJDDT), 16 (23). ISSN 0975-4415

Text
Scopus article 2.pdf - Published Version
Download (322kB)

Official URL: https://ijddt.com/

Abstract

ABSTRACT
Amaranthus tricolor L. (Amaranthaceae), commonly known as edible amaranth or Chinese spinach, is a nutrient-dense
leafy vegetable with significant ethnomedicinal importance. The present study aimed to evaluate the phytochemical
composition and pharmacological activities of the hydroalcoholic extract of A. tricolor stem and roots. Preliminary
phytochemical screening revealed the presence of key bioactive constituents, including alkaloids, carbohydrates,
glycosides, saponins, proteins, amino acids, polyphenols, and terpenoids. Quantitative analysis indicated a considerable
total phenolic content (1.5146 µg/g), suggesting strong antioxidant potential. The in vitro anti-diabetic activity
demonstrated effective α-amylase inhibition with an IC₅₀ value of 115.98 µg/mL, comparable to the standard drug acarbose
(125.81 µg/mL). Anti-inflammatory activity assessed by the human red blood cell (HRBC) membrane stabilization method
showed dose-dependent inhibition, with an IC₅₀ value of 177.42 µg/mL, compared to diclofenac (114.03 µg/mL).
Antioxidant activity evaluated using the DPPH radical scavenging assay exhibited significant free radical inhibition with
an IC₅₀ value of 47.77 µg/mL. The extract demonstrated appreciable iron content, indicating its potential role in managing
iron deficiency anemia. The observed pharmacological activities may be attributed to the presence of phenolic compounds
and other phytoconstituents. The findings suggest that A. tricolor stem and root extracts possess promising anti-diabetic,
anti-inflammatory, and antioxidant properties, along with nutritional benefits. Further in vivo and clinical studies are
required to validate these results and elucidate the underlying mechanisms of action.
Keywords: Amaranthus tricolor L.; Phytochemicals; Anti-diabetic activity; Anti-inflammatory activity and Antioxidant
activity.

Item Type:	Article
Subjects:	Agriculture > Plant Sciences
Domains:	Agriculture
Depositing User:	Mr IR Admin
Date Deposited:	12 May 2026 10:45
Last Modified:	13 May 2026 04:08
URI:	https://ir.vistas.ac.in/id/eprint/18957

Actions (login required)

: View Item