Intra-University Technical Project Expo-Avishkar 5.0

The current invention pertains to polyherbal topical formulation and the process of its preparation
as an agent used to treat wounds. It also includes extracts of Centella asiatica (Vallari) and
Calendula officinalis , which have been chosen due to their complementary action in stimulating
tissue regeneration, decreasing inflammation, and controlling the oxidative stress. It is aimed at
developing a safe, cost-effective, and multifunctional herbal wound care system. Plant materials
are hydroalcoholically extracted to produce a semi-solid extract which is subsequently
incorporated into a base that is pharmaceutically acceptable e.g. a cream or gel. The formulation
will be used to improve wound healing through the maintenance of a moist environment, stability,
and patient acceptability.Early physicochemical and physical analyses, such as appearance,
homogeneity, PH, viscosity, spreadability and extrudability were conducted to ascertain its topical
application. The phytochemical screening showed that triterpenoids, flavonoids, and phenolic
compounds were present and these ones are associated with therapeutic effect in wound
healing.Formulation quality was evaluated based on the standard guidelines so as to achieve
consistency. The formulation also displayed a high in-vitro antioxidant activity meaning that it can
be used to control oxidative stress in wounds. The batch-to-batch reproducibility is guaranteed by
analytical standardization by chromatographic methods like HPTLC. Altogether, the invention
provides a scalable and environmentally friendly methodology to address effective polyherbal
topical formulations to be used as wound care and in dermatology.
KEY WORDS : Centella asiatica; Calendula officinalis; Wound healing; Antioxidant activity