Progress and Perspectives in Poly(meth) Acrylate/Acrylamide Derived Biosensing Technologies

Poly(meth)acrylate and vinyl-based polymers have emerged as highly versatile functional materials for next-generation sensing
technologies. Their tunable architectures, chemical stability, and ability to incorporate stimuli-responsive, fluorescent, or bioactive
moieties enable precise detection in biomedical, environmental, and chemical systems. Recent advancements in controlled radical
polymerization, including ATRP, RAFT, NMP methods, have significantly improved structural control, allowing the fabrication
of well-defined polymeric sensors with high sensitivity and selectivity. Methacrylate derived hydrogels, copolymers, and block
architectures support applications ranging from molecular recognition and targeted drug delivery to imaging, electrochemical
sensing, and pollutant detection. Incorporation of functional groups such as peptides, metal-binding ligands, and imaging agents
has enabled advanced biosensors capable of detecting biomarkers, cancer cells, ions, explosives, and reactive species. Progress in
multimodal imaging, fluorescent tagging, and molecular imprinting further expands their applicability. This review summarizes
major developments in polymer synthesis and sensor design, highlights structure property function relationships, and outlines
emerging opportunities for miniaturized, high-performance polymer-based sensing platforms. The insights provided aim to guide
future innovation in smart, adaptive, and multifunctional polymeric sensors.