Therapeutic potential of Jasminum species: Exploring anti-inflammatory, antioxidant and anticancer properties

Jasminum species, commonly referred to as Jasmine, are famous for their aromatic, fragrant flowers and
ornamental value. However, over recent decades, Jasminum species have drawn a lot of interest due to
their promising medicinal potential, especially in the areas of antioxidant, anti-inflammatory, and
anticancer actions. The medical effects of these Jasminum species have been linked to a wide variety of
bioactive components, including terpenoids, alkaloids, flavonoids, and phenolic compounds. The ability
of Jasminum species to suppress the synthesis of pro-inflammatory cytokines (TNF-, IL-6, and IL-1)
and alter important inflammatory pathways, such as NF-B and COX-2, is thought to be responsible for
their anti-inflammatory properties. Free radicals and reactive oxygen species (ROS), are linked to aging
and a number of disorders connected to oxidative stress, can be neutralized by the antioxidant qualities of
Jasminum species, which are mainly fuelled by flavonoids and phenolic substances like quercetin and
kaempferol. By enhancing the activity of endogenous antioxidant enzymes like superoxide dismutase
(SOD) and catalase (CAT), Jasminum species demonstrate potential as protective agents against oxidative
damage in cells and tissues. The Jasminum species exhibit significant anticancer properties. Their bioactive
compounds induce programmed cell death in cancer cells, regulate cell cycle arrest, and inhibit metastatic
spread by modulating signalling pathways such as PI3K/Akt, MAPK, and Wnt/-catenin.