BENEFICIAL EFFECTS OF SESAMOL IN BRAIN OF ROTENONE-INDUCED ANIMAL MODEL OF PARKINSON’S DISEASE

To investigate the beneficial effect of sesamol on neurotransmitters of rotenoneinduced
animal model of Parkinson’s disease. Male Wistar albino rats were subjected to
study for 60 days (n=6: I- vehicle control, II- rotenone (3 mg/kg.B.wt intraperitoneal), IIIrotenone
+ sesamol (50 mg/kg.B.wt intraperitoneal), IV- rotenone + sesamol + L-DOPA (10
mg/kg.B.wt oral), V- rotenone + L-DOPA). The brains of the experimental animals were
homogenized, centrifuged and subjected to analyze the neurotransmitters such as dopamine,
epinephrine, nor epinephrine and serotonin. Rotenone has developed neurochemical
alterations in the brain of experimental animals whereas administration of sesamol has
reduced the alterations induced by rotenone. The results also prove that sesamol can serve as
a beneficial compound in the maintenance of neurotransmitters in Parkinsonian models.