Albosteroid, A Steroidal Glycoside Derived From Morus Mongolica, Had A Protective Role In Preventing Nephrotoxicity In Rats Exposed To Paracetamol

Paracetamol (PCM) has an acceptable safety profile when used at the recommended dosage. Nevertheless, an overdose might cause kidney damage, with oxidative stress serving as one of the likely pathways. In this study, the effect of moralbosteroid isolated from Morus Mongolica stem bark [50 mg/kg and 100 mg/kg] on PCM-induced nephrotoxicity was evaluated. There were four sets of six rats containing rats. Other groups were treated with PCM alone (2 g/kg), 50 mg/kg albosteroid + PCM (2 g/kg), and 100 mg/kg albosteroid + PCM (2 g/kg), respectively. The control group received 1 ml vehicle. All of the materials were delivered orally. Albosteroid treatment at dosages of 50 and 100 mg/kg inhibits PCM-induced nephrotoxicity and oxidative damage to the kidney, as demonstrated by a substantially decreased level of blood urea and serum creatinine (P0.01, P0.05, and P0.001). In addition, a substantial rise (P0.05) in glutathione (GSH) concentration and a significant reduction (P0.001) in lipid peroxidation (LPO) were detected. Albosteroid's renoprotective qualities were shown by a decrease in the degree of nephritic cell death, as indicated by histological results. In addition, it was discovered that 100 mg/kg of albosteroid had stronger protective benefits than 50 mg/kg. Albosteroid has a protective effect against PCM-induced nephrotoxicity, the mechanism of which is likely mediated by its antioxidant activity. Keywords: albosteroid, Antioxidant, Oxidative stress, Nephrotoxicity, Paracetamol