Hepatoprotective activity of Albosteroid, a Morus Mongolica triterpenic glycoside ester in experimental animals

Ethnopharmacological relevance: Morus Mongolica has historically been used in China to treat and prevent a wide
range of ailments.
Materials and methods: Albosteroid from Morus Mongolica was tested for its hepatoprotective properties. ALT, AST,
ALP, total bilirubin, and total protein levels, as well as antioxidant enzymes including SOD, CAT, and GPx, GST, and LPO
levels, were all examined in the context of CCL4-induced hepatocellular carcinogenesis.
Results: Albosteroid, in a dose-dependent way, effectively returned towards normality the abnormal levels of serum
ALT, AST, ALP, TB, and TP. Histopathological examination of rat liver slices was performed in addition to the
biochemical tests that were already conducted. The reversal of the CCl4-diminished activity of antioxidant enzymes
such as SOD, Cat, GPx, GST and the lowered CCl4-elevated level of LPO was likewise considerable and dose-dependent.
The free radical processes were reduced by scavenging hydroxyl radicals, which albosteroid effectively prevented
from increasing in blood levels. A significant rise in the amount of endogenous antioxidant enzymes in CCL4-induced
hepatocellular carcinogenesis is also caused by this drug's effect on LPO levels.
Conclusion: The findings of this research reveal that albosteroid may help prevent liver cancer in rats that have been
exposed to CCL4-induced carcinogenesis.